Copaiba oil resins are extensively commercialized in Brazil as capsules or crude oil and used as anti-inflammatory and anti-septic. Comparative pharmacological studies between different species of Copaiba oils are scarce. In the present work we compared the antinociceptive activity of two Amazonian Copaiba oils (Copaifera multijuga Hayne and Copaifera reticulata Ducke, Fabaceae) administered by oral route using peripheral (acetic acid-induced abdominal writhing and formalin), spinal (tail flick) and supra-spinal (hot plate) models. Results demonstrated that the Copaiba oils did not develop toxic effects. Doses ranging from 30 to 150 mg/kg were enough to significantly develop peripheral antinociceptive effect. All Copaiba oils demonstrate central activity but with less effect on supra-spinal regions of the brain. Administration of the opioid receptor antagonist, naloxone completely inhibited the antinociceptive effect induced by both Copaiba oils. Our results indicate that Copaiba oils demonstrate peripheral and central antinociceptive effect. This new comprobate effect may be useful in the treatment of algesic disorders.

译文

Copaiba油树脂在巴西作为胶囊或原油广泛商业化,并用作抗炎和防腐。缺乏不同种类的Copaiba油之间的比较药理学研究。在目前的工作中,我们比较了两种亚马逊Copaiba油 (Copaifera multijuga Hayne和Copaifera reticulata Ducke,Fabaceae) 的抗伤害感受活性,该方法通过口服途径使用外周 (乙酸诱导的腹部扭动和福尔马林),脊柱 (甩尾) 和脊髓上 (热板) 模型。结果表明,Copaiba油不会产生毒性作用。30至150 mg/kg的剂量足以显着发展外周抗伤害感受作用。所有Copaiba油均表现出中枢活性,但对大脑脊髓上区域的影响较小。服用阿片受体拮抗剂,纳洛酮完全抑制了两种Copaiba油诱导的抗伤害感受作用。我们的结果表明,Copaiba油具有外围和中央抗伤害作用。这种新的药物作用可能有助于治疗痛觉障碍。

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