PURPOSE:Based on the observation that epileptic seizures can occur at specific times of the day, we looked for daily variation in an intracranial electrographic feature used by a responsive neurostimulator system to detect seizures. METHODS:A computationally efficient measure of intracranial EEG energy or complexity, the line length baseline, was calculated and reported by an external responsive neurostimulator during a clinical trial of device safety. Data were obtained from 24 consecutive patients with medically intractable epilepsy undergoing intracranial monitoring over 2 to 54 days to localize the seizure onset zone. Measurements from individual subjects made at different times of day over many days were displayed on a single 24-h cycle and fit with a cosine function to characterize the time of the maximum value. The timing of epileptic seizures was also noted. RESULTS:The time of the maximum line length baseline value had a bimodal distribution with relative peaks at 05:30 and 15:00 hours. The time of the maximum value did not associate with specific brain regions, except that a nocturnal peak was not measured from temporal neocortex. The temporal distribution of maximum values was similar to the timing of epileptic seizures. CONCLUSION:The line length baseline feature of the intracranial EEG shows daily variation with location specific characteristics within individual subjects.

译文

目的:基于观察到癫痫性癫痫发作可能在一天的特定时间发生,我们寻找了反应性神经刺激系统用来检测癫痫发作的颅内电描记图特征的每日变化。
方法:在设备安全性临床试验期间,由外部响应神经刺激器计算并报告了颅内脑电图能量或复杂度的有效计算方法,即线长基线。从连续2到54天内接受颅内监测以定位癫痫发作区的连续24例医学上难治的癫痫患者获得数据。在单个一天的24小时周期内显示在一天中的不同时间进行的对单个对象的测量,并具有余弦函数以表征最大值的时间。还注意到了癫痫发作的时间。
结果:最大线长基线值的时间呈双峰分布,相对峰出现在05:30和15:00小时。最大值的时间与特定的大脑区域无关,只是没有从颞新皮层测量到夜间的峰值。最大值的时间分布类似于癫痫发作的时间。
结论:颅内脑电图的线长基线特征显示个体受试者中具有特定位置特征的每日变化。

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