Our view on the bacterial responses to the aerobic degradation of aromatic compounds has been enriched considerably by the current omic methodologies and systems biology approaches, revealing the participation of intricate metabolic and regulatory networks. New enzymes, transporters, and specific/global regulatory systems have been recently characterized, and reveal that the widespread biodegradation capabilities extend to unexpected substrates such as lignin. A completely different biochemical strategy based on the formation of aryl-CoA epoxide intermediates has been unraveled for aerobic hybrid pathways, such as those involved in benzoate and phenylacetate degradation. Aromatic degradation pathways are also an important source of metabolic exchange factors and, therefore, they play a previously unrecognized biological role in cell-to-cell communication. Beyond the native bacterial biodegradation capabilities, pathway evolution as well as computational and synthetic biology approaches are emerging as powerful tools to design novel strain-specific pathways for degradation of xenobiotic compounds.

译文

当前的omic方法和系统生物学方法极大地丰富了我们对细菌对芳香族化合物需氧降解的反应的观点,揭示了复杂的代谢和调节网络的参与。最近已经表征了新的酶,转运蛋白和特定/全球调节系统,并揭示了广泛的生物降解能力扩展到意想不到的底物,例如木质素。基于芳基-CoA环氧化物中间体形成的完全不同的生化策略已针对好氧杂化途径 (例如涉及苯甲酸酯和乙酸苯酯降解的途径) 展开。芳香降解途径也是代谢交换因子的重要来源,因此,它们在细胞间通讯中起着以前未被认识的生物学作用。除了天然细菌的生物降解能力外,途径的进化以及计算和合成生物学方法正在成为设计新的菌株特异性途径以降解异种生物化合物的强大工具。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录