Reactive oxygen species (ROS), normally generated through biologic processes, may damage DNA, lipids, and proteins. ROS are balanced through enzymatic mechanisms and exogenous antioxidants; imbalance results in oxidative stress. Limited data suggest an association between oxidative stress and breast cancer. We evaluated pre-diagnostic plasma fluorescent oxidation products (FlOP), a global biomarker of oxidative stress, and breast cancer risk in a nested case-control study in the Nurses' Health Study. Participants provided two blood samples (1989-1990 and 2000-2002) (N = 18,743). 377 women developed breast cancer between the second collection and June 1, 2006. Cases were matched to 377 controls. Relative fluorescent intensity at three different excitation/emission wavelengths (FlOP_360, FlOP_320, FlOP_400) were quantified in both samples, providing distant (≥10 years before diagnosis) and proximate (≤6 years before diagnosis) measures of oxidative stress. We observed no association between FlOP and breast cancer risk in proximate or distant samples (e.g., proximate extreme quartiles: FlOP_360, RR 0.8, 95 % CI 0.5-1.3, p trend = 0.49; FlOP_320, RR 1.1, 95 % CI 0.7-1.7, p trend = 0.53; FlOP_400, RR 1.3, 95 % CI 0.8-2.0, p trend = 0.80). In general no association was observed when cross-classifying or averaging proximate and distant exposure (e.g., extreme quartile of averages: FlOP_360, OR 0.9, 95 % CI 0.6-1.4, p trend = 0.82; FlOP_400, OR 0.9, 95 % CI 0.6-1.4, p trend = 0.55), with the exception of a significant trend for average FlOP_320 (extreme quartiles, OR 1.6, 95 % CI 1.0-2.4, p trend = 0.02). We did not observe important associations between FlOP and breast cancer risk in this large prospective study, though our data suggest women with consistently high FlOP_320 may be at increased risk.

译文

:通常通过生物过程产生的活性氧(ROS)可能会损坏DNA,脂质和蛋白质。 ROS通过酶促机制和外源性抗氧化剂来平衡。不平衡会导致氧化应激。有限的数据表明氧化应激与乳腺癌之间存在关联。在“护士健康研究”中的嵌套病例对照研究中,我们评估了诊断前的血浆荧光氧化产物(FlOP),氧化应激的全球生物标志物和乳腺癌的风险。参与者提供了两个血液样本(1989-1990年和2000-2002年)(N = 18,743)。在第二批收集到2006年6月1日之间,有377名妇女患了乳腺癌。病例与377名对照者匹配。在两个样品中都对三个不同激发/发射波长(FlOP_360,FlOP_320,FlOP_400)的相对荧光强度进行了定量,从而提供了远距离(诊断前≥10年)和接近(诊断前≤6年)的氧化应激指标。我们观察到在近或远样本中FlOP与乳腺癌风险之间没有关联(例如,近四分位数:FlOP_360,RR 0.8,95%CI 0.5-1.3,p趋势= 0.49; FlOP_320,RR 1.1,95%CI 0.7-1.7 ,p趋势= 0.53; FlOP_400,RR 1.3,95%CI 0.8-2.0,p趋势= 0.80)。通常,对近距离和远距离暴露进行交叉分类或取平均值时,未观察到关联(例如,平均值的极四分位数:FlOP_360,或0.9,95%CI 0.6-1.4,p趋势= 0.82; FlOP_400,或0.9,95%CI 0.6 -1.4,p趋势= 0.55),平均FlOP_320的显着趋势除外(极四分位数,或1.6,95%CI 1.0-2.4,p趋势= 0.02)。在这项大型的前瞻性研究中,我们并未观察到FlOP与乳腺癌风险之间的重要关联,尽管我们的数据表明,持续高FlOP_320的女性可能处于增加的风险中。

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