Here we describe the cloning of the human Achaete Scute Homologue 2 (HASH2) gene, officially designated ASCL2 (Achaete Scute complex like 2), a homologue of the Drosophila Achaete and Scute genes. In mouse, this gene is imprinted and maps to chromosome 7. We mapped the human homologue close to IGF2 and H19 at 11p15.5, the human region syntenic with mouse chromosome 7, indicating that this imprinted region is highly conserved in mouse and man. HASH2 is expressed in the extravillus trophoblasts of the developing placenta only. The lack of HASH2 expression in non-malignant hydatidiform (androgenetic) moles indicates that HASH2 is also imprinted in man.

译文

在这里,我们描述了人类Achaete Scute同源物2(HASH2)基因的克隆,该基因正式命名为ASCL2(Achaete Scute复合物类似2),是果蝇Achaete和Scute基因的同源物。在小鼠中,该基因被印迹并定位于7号染色体。我们在11p15.5处绘制了与IGF2和H19接近的人类同源基因,该区域与小鼠7号染色体呈同义关系,表明该印迹区域在小鼠和人类中高度保守。 HASH2仅在发育中的胎盘的绒毛外滋养细胞中表达。非恶性葡萄胎(雄激素性)痣中缺乏HASH2表达,这表明HASH2也被印在人体内。

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