Patients with familial hypercholesterolemia (FH) are especially at risk for premature cardiovascular disease (CVD). Recent studies revealed C-reactive protein (CRP) as a strong predictor of future first or recurrent CVD events, suggesting that CRP plays an important role in the development of atherosclerosis. The aim of this study was to evaluate the effect of one year of simvastatin treatment on serum levels of CRP and to assess the influence of risk factors for CVD on CRP concentrations in patients with FH. We measured baseline CRP levels in 337 patients with FH. A second blood sample, collected after one year of treatment with simvastatin (20--40 mg once daily) was measured in a subgroup of 129 patients. Patients with CVD present at baseline had significantly higher serum levels of CRP (2.26 mg/l versus 1.55 mg/l, P<0.001). CRP levels were associated with smoking, body mass index, age, levels of triglycerides (TG), and the use of NSAIDs or anticoagulation drugs. Simvastatin therapy significantly improved lipid profiles in the intervention group. There was a small, but non-significant decrease of CRP levels upon treatment. CRP decreased from 1.51 mg/l median (interquartile range (IQR) 0.76--3.41) at baseline to 1.24 mg/l median (IQR 0.72--2.92) after treatment, (P=0.328). In conclusion, CRP levels were associated with the presence of CVD in FH patients. Simvastatin therapy had no significant effect on CRP levels in these patients.

译文

:家族性高胆固醇血症(FH)的患者特别容易患早发性心血管疾病(CVD)。最近的研究表明,C反应蛋白(CRP)是将来发生首次或复发CVD事件的有力预测指标,表明CRP在动脉粥样硬化的发展中起着重要作用。这项研究的目的是评估辛伐他汀治疗一年对CRP血清水平的影响,并评估CVD危险因素对FH患者CRP浓度的影响。我们测量了337例FH患者的基线CRP水平。在129名患者的亚组中,使用辛伐他汀治疗一年(20--40 mg,每天一次)后收集的第二份血液样品进行了测量。基线时出现CVD的患者血清CRP水平明显升高(2.26 mg / l对1.55 mg / l,P <0.001)。 CRP水平与吸烟,体重指数,年龄,甘油三酸酯(TG)水平以及NSAID或抗凝药物的使用有关。辛伐他汀疗法可显着改善干预组的血脂水平。治疗后,CRP水平有少量但无明显下降。治疗后CRP从基线时的中位数1.51 mg / l(四分位间距(IQR)0.76--3.41)降至治疗后的1.24 mg / l中位数(IQR 0.72--2.92)(P = 0.328)。总之,在FH患者中CRP水平与CVD的存在有关。辛伐他汀疗法对这些患者的CRP水平无明显影响。

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