OBJECTIVE:To test the performance of CK5/6 for the differentiation between mesothelioma, adenocarcinoma and benign mesothelia/proliferations in effusion cytology. STUDY DESIGN:CKS/6 immunocytochemistry was applied to ethanol-fixed cytospin preparations from 74 benign and malignant effusions. RESULTS:Reactivity was seen in 7 of 8 mesotheliomas and in 9 of 11 benign mesothelial proliferations but also in 11 of l7 pulmonary adenocarcinomas and in 12 of 31 adenocarcinomas of nonpulmonary origin. Reactivity was also found in 3 of 5 non-small cell lung carcinomas and 1 of 1 squamous carcinoma. CONCLUSION:CK5/6 reactivity was found in a considerable proportion of metastatic adenocarcinomas of pulmonary and nonpulmonary origin. The high reactivity rate in pulmonary adenocarcinomas disagrees with the results obtained with histologic sections from solid tumor tissue, and CK5/6 seems to be of very limited value as an additional marker in effusion cytology.

译文

目的:探讨CK5 / 6在间质细胞学中对间皮瘤,腺癌和良性间皮细胞/增生的分化能力。
研究设计:CKS / 6免疫细胞化学被应用于来自74例良性和恶性积液的乙醇固定的细胞离心制备物中。
结果:在8个间皮瘤中有7个和11个良性间皮增生中有9个反应性,但在17个肺腺癌中有11个和31个非肺源性腺癌中均可见到反应性。在5个非小细胞肺癌中有3个和1个鳞状癌中有1个也发现了反应性。
结论:在相当一部分肺和非肺源性转移性腺癌中发现了CK5 / 6反应性。肺腺癌的高反应率与从实体瘤组织的组织学切片获得的结果不同,并且CK5 / 6作为积液细胞学中的其他标志物似乎价值非常有限。

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