RNA editing is a source of molecular diversity that regulates the functional repertoire of animal transcriptomes. Multiple studies in Drosophila have revealed that conserved editing events can be a source of evolutionary adaptations, and there is a solid body of evidence linking editing and the fine-tuning of neural genes, which are often targeted by insecticides used in vector control. Yet, despite these suggestive connections, genome-wide analyses of editing in insect vectors are conspicuously lacking. Future advances will require complementing the growing wealth of vector genomes with targeted transcriptome analyses. Here, we review recent investigations of the genetic footprints of adaptive RNA editing in insects and provide an overview of new methodologies applicable to studies of RNA editing in insect vectors.

译文

RNA编辑是调节动物转录组功能的分子多样性的一个来源。在果蝇中的多项研究表明,保守的编辑事件可能是进化适应的来源,并且存在将编辑和神经基因的微调联系起来的可靠证据,而神经基因通常是载体控制中使用的杀虫剂所针对的。然而,尽管有这些暗示性的联系,但是仍然明显缺乏对昆虫载体编辑的全基因组分析。未来的发展将需要通过靶向转录组分析来补充日益丰富的载体基因组。在这里,我们回顾了昆虫中自适应RNA编辑的遗传足迹的最新研究,并提供了适用于昆虫载体RNA编辑研究的新方法的概述。

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