We compared serotype distributions of Streptococcus pneumoniae isolates from patients aged <5 and o5 years with invasive pneumococcal disease in New South Wales, Australia, and antibiotic susceptibilities of isolates from the <5 years age group only, before (2002–2004) and after(2005–2009) introduction of the 7-valent pneumococcal conjugate vaccine (PCV7). Overall, there were significant decreases in the mean annual number of referred isolates (770 vs. 515) and the proportion belonging to PCV7 serotypes (74% vs. 38%), but non-PCV7 serotypes, particularly 19A, increased (5% vs. 18%). All changes were more marked in the <5 years age group.Susceptibility testing of isolates from the <5 years age group showed variation in resistance between serotypes, but significant overall increases in penicillin non-susceptibility (23% vs. 31%),ceftriaxone resistance (2% vs. 12%) and multidrug resistance (4% vs. 7%) rates ; erythromycin resistance fell (32% vs. 25%). Continued surveillance is needed to monitor changes following the introduction of 13-valent PCV in 2012.

译文

我们比较了澳大利亚新南威尔士州 <5岁和o5岁侵袭性肺炎球菌疾病患者肺炎链球菌分离株的血清型分布,以及 <5岁年龄组分离株的抗生素敏感性,在 (2002-2004) 和 (2005-2009) 引入7价肺炎球菌结合疫苗 (PCV7) 之前。总体而言,平均年转诊分离株数 (770对515) 和属于PCV7血清型的比例显著下降 (74% 对38%),但non-PCV7血清型,特别是19A,增加 (5% 对18%)。所有变化在 <5岁年龄组中更为明显。来自 <5岁年龄组的分离株的药敏试验显示血清型之间的耐药性差异,但青霉素非药敏总体显着增加 (23% 对31%),头孢曲松耐药率 (2% 对12%) 和多药耐药率 (4% 对7%); 红霉素耐药率下降 (32% 对25%)。在引入13价PCV 2012年后,需要持续监测以监测变化。

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