OBJECTIVE:We examined the independent relationships between objectively measured physical activity and insulin resistance in Portuguese children. RESEARCH DESIGN AND METHODS:This is a school-based, cross-sectional study in 147 randomly selected girls (aged 9.8 +/- 0.3 years; 27.8 +/- 9.3% body fat) and 161 boys (aged 9.8 +/- 0.3 years; 22.0 +/- 9.2% body fat). Physical activity was assessed by the Actigraph accelerometer for 4 days and summarized as time spent sedentary (accelerometer counts <500/min), in light-intensity (accelerometer counts 500-2,000/min), and in moderate- and vigorous-intensity activity (accelerometer counts >2,001/min). We measured total and central fat mass by dual-energy X-ray absorptiometry. Insulin resistance was expressed as the homeostasis model assessment score. RESULTS:Time (min/day) spent sedentary was significantly and positively associated with insulin resistance (beta-coefficient = 0.001 [95% CI 0.0002-0.002]; P = 0.013). Time spent in moderate- and vigorous-intensity physical activity (-0.002 [-0.003 to -0.001]; P = 0.0009) and overall physical activity (-0.001 [-0.008 to 0.003]; P < 0.0001) were significantly and inversely associated with insulin resistance. All associations remained statistically significant, although they were attenuated after further adjustments for sex, birth weight, sexual maturity, and total or central fat mass (P < 0.03). CONCLUSIONS:Physical activity is associated with insulin resistance independent of total and central fat mass in children. Our results emphasize the importance of decreasing sedentary behavior and increasing time spent in moderate- and vigorous-intensity activity in children, which may have beneficial effects on metabolic risk factors regardless of the degree of adiposity.

译文

目的:我们研究了客观测量的体育锻炼与葡萄牙儿童胰岛素抵抗之间的独立关系。
研究设计和方法:这是一项基于学校的横断面研究,研究对象是147个随机选择的女孩(9.8 /-0.3岁; 27.8 /-9.3%体脂)和161个男孩(9.8 /-0.3岁; 22.0 / -9.2%的体内脂肪)。通过Actigraph加速度计评估了4天的身体活动,并总结为久坐的时间(加速度计计数<500 / min),光强度(加速度计计数500-2,000 / min)以及中度和剧烈强度的运动(加速度计计数> 2,001 / min)。我们通过双能X射线吸收法测量了总脂肪和中央脂肪量。胰岛素抵抗表示为稳态模型评估得分。
结果:久坐的时间(分钟/天)与胰岛素抵抗显着正相关(β系数= 0.001 [95%CI 0.0002-0.002]; P = 0.013)。中度和剧烈运动所花费的时间(-0.002 [-0.003至-0.001]; P = 0.0009)和整体运动(-0.001 [-0.008至0.003]; P <0.0001)与以下各项显着且呈负相关胰岛素抵抗。尽管对性别,出生体重,性成熟度和总或中心脂肪量作进一步调整后,所有相关性均减弱,但所有相关性仍具有统计学意义(P <0.03)。
结论:儿童的体育活动与胰岛素抵抗有关,而与总脂肪和中央脂肪无关。我们的研究结果强调了减少久坐行为和增加儿童中度和剧烈运动时间的重要性,这与肥胖程度无关,可能对代谢危险因素产生有益影响。

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