Toll like receptors (TLRs) are essential molecules implicated in both innate and adaptive immune response. Polymorphisms in TLR gene have been associated with various infectious diseases and autoimmune disorders. Role of TLR9 has been elegantly demonstrated in both human systemic lupus erythematosus (SLE) and mice model of lupus. In the present study we investigated association of TLR-9 promoter polymorphisms (T-1237C and T-1486C) with susceptibility/resistance to SLE in an Eastern Indian state which is endemic to parasitic diseases. 210 Female SLE patients who fulfilled the American College of Rheumatology criteria were enrolled along with matched healthy controls from Odisha, India. TLR-9 polymorphisms (T-1237C and T-1486C) were typed by polymerase chain reaction followed by restriction fragment length polymorphism. For meta-analysis, relevant literatures were searched from PubMed database and comprehensive meta-analysis V2 software was employed for analysis. Allele and genotype frequency of TLR-9 promoter polymorphisms (T-1237C and T-1486C) were comparable among SLE patients and controls. Further, meta-analysis of earlier reports and present study did not reveal a significant association of TLR-9 (T-1237C and T-1486C) polymorphisms with SLE. Data from the present study suggest that TLR-9 promoter polymorphisms are not associated with susceptibility to SLE in an area endemic to parasitic diseases.

译文

:Toll样受体(TLRs)是与先天和适应性免疫反应有关的必需分子。 TLR基因的多态性与多种传染病和自身免疫性疾病有关。 TLR9的作用已在人系统性红斑狼疮(SLE)和狼疮小鼠模型中得到了很好的证明。在本研究中,我们调查了在印度洋东部寄生虫病流行州,TLR-9启动子多态性(T-1237C和T-1486C)与对SLE的敏感性/耐药性之间的关系。纳入了210名符合美国风湿病学会标准的女性SLE患者以及来自印度奥里萨邦的相匹配的健康对照。 TLR-9多态性(T-1237C和T-1486C)通过聚合酶链式反应,然后进行限制性片段长度多态性进行分型。对于荟萃分析,从PubMed数据库中搜索相关文献,并使用综合的荟萃分析V2软件进行分析。在SLE患者和对照组中,TLR-9启动子多态性(T-1237C和T-1486C)的等位基因和基因型频率相当。此外,对早期报道和本研究的荟萃分析未发现TLR-9(T-1237C和T-1486C)多态性与SLE有显着相关性。来自本研究的数据表明,在寄生虫病流行地区,TLR-9启动子多态性与SLE易感性无关。

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