BACKGROUND/AIMS:Liver metastases are associated with poor prognosis in patients with colorectal cancer (CRC). The objective of this study is to determine the possible indicators in identifying the predictive value of serum CEA, CA19-9 and CA-125 in diagnosis of liver metastases from CRC in the Chinese population. METHODOLOGY:We randomly selected 101 CRC patients with liver metastases and 81 patients without liver metastases. Several clinical pathological factors were analyzed for the correlation with liver metastases. The predictive value of CEA, CA19-9 and CA-125 for liver metastases from CRC was evaluated. RESULTS:There was no significant difference in gender, age, hepatitis B history, serum AFP level or lesion location. Patients with liver metastases had a tendency to have higher serum CEA, CA19-9 and CA-125 level. Multivariate analysis revealed that serum CEA level (p<0.001), CA19-9 level (p<0.001) and CA-125 level (p=0.001) were independent prognostic predictors for liver metastases. Combination of CEA, CA19-9 and CA-125 can enhance their sensitivity in diagnosis of synchronous and metachronous liver metastases. Serum CA19-9 level, combined test of CA19-9 and CA-125, combined test of triple markers have higher sensitivities in synchronous metastasis than those in metachronous metastasis. CONCLUSIONS:Combination test would enhance the sensitivities of serum CEA, CA19-9 and CA-125 levels, which are important in predicting liver metastases from CRC in the Chinese population, either synchronous or metachronous.

译文

背景/目的:肝转移与大肠癌(CRC)患者预后不良有关。这项研究的目的是确定可能的指标,以鉴定血清CEA,CA19-9和CA-125对中国人群CRC肝转移的诊断价值。
方法:我们随机选择101例有肝转移的CRC患者和81例无肝转移的CRC患者。分析了几种临床病理因素与肝转移的相关性。评估了CEA,CA19-9和CA-125对CRC肝转移的预测价值。
结果:性别,年龄,乙型肝炎病史,血清AFP水平或病变部位均无显着差异。有肝转移的患者倾向于有更高的血清CEA,CA19-9和CA-125水平。多变量分析表明,血清CEA水平(p <0.001),CA19-9水平(p <0.001)和CA-125水平(p = 0.001)是肝转移的独立预后指标。 CEA,CA19-9和CA-125的组合可增强其在同步和异时肝转移癌诊断中的敏感性。血清CA19-9水平,CA19-9和CA-125的联合检测,三标记物的联合检测在同步转移中的敏感性高于在同步转移中的敏感性。
结论:联合试验可提高血清CEA,CA19-9和CA-125水平的敏感性,这对预测中国人群CRC同步或异时肝转移具有重要意义。

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