Plasminogen activator inhibitor-1 (PAI-1) is an inhibitor of fibrinolysis. Increased plasma PAI-1 levels play an essential role in the pathogenesis of cardiovascular risk and other diseases associated with thrombosis. The 4G/5G polymorphism of the PAI-1 promoter region has been extensively studied in different populations. We studied 160 healthy unrelated Lebanese individuals using a reverse hybridization PCR assay to detect the 5G/5G, 4G/5G and, 4G/4G genotypes of the PAI-1 gene and the frequencies of the 4G and 5G alleles. We found that 4G/5G genotype was the most prevalent (45.6%) followed by 5G/5G (36.9%) and 4G/4G (17.5%). The frequencies of the 4G and 5G alleles were calculated to be 0.403 and 0.597, respectively. Compared to other ethnic communities, the Lebanese population was found to harbour a relatively high prevalence of the rare 4G allele. This, in turn, may predispose this population to develop cardiovascular diseases and other thrombotic clinical conditions. This study aids to enhance our understanding of the genetic features of the Lebanese population.

译文

:Plasminogen activator inhibitor-1(PAI-1)是纤维蛋白溶解抑制剂。血浆PAI-1水平升高在心血管风险和其他与血栓形成有关的疾病的发病机理中起着至关重要的作用。 PAI-1启动子区域的4G / 5G多态性已在不同人群中进行了广泛研究。我们使用反向杂交PCR方法研究了160名健康的黎巴嫩无关个体,以检测PAI-1基因的5G / 5G,4G / 5G和4G / 4G基因型以及4G和5G等位基因的频率。我们发现4G / 5G基因型是最普遍的(45.6%),其次是5G / 5G(36.9%)和4G / 4G(17.5%)。计算得出4G和5G等位基因的频率分别为0.403和0.597。与其他种族社区相比,发现黎巴嫩人口中稀有4G等位基因的患病率较高。反过来,这可能使该人群容易患上心血管疾病和其他血栓形成性临床状况。这项研究有助于增进我们对黎巴嫩人口遗传特征的了解。

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