Although asthmatic patients are known to have increased levels of IgG antibody against house dust mite (HDM), it is not clear whether or not the presence of HDM-specific IgG antibody is associated with the etiological mechanism of asthma. To address this problem, we evaluated the relationship between HDM-specific IgG antibody levels and incidence of asthma in a general pediatric population. IgE and IgG antibody levels against Dermatophagoides farinae (Df) were examined by RAST and ELISA in a total of 722 randomly selected schoolchildren including 26 subjects with asthma, and the relative prevalence rates of asthma in this population were evaluated in relation to both Df-specific IgE and IgG levels. The incidence of asthma correlated not only with levels of Df-specific IgE, but also with those of Df-specific IgG. There was a significant correlation between Df-specific IgE and IgG levels both in the total population and in the asthmatic children. Because IgG and IgE responses occurred in parallel in this population, the clinical significance of HDM-specific IgG anti-body remains unclear. However, our findings have suggested that clinical expression of asthma in children is primarily dependent on their capacity to mount a immune response to HDM, which includes both IgE and IgG responses.

译文

尽管已知哮喘患者的抗屋尘螨(HDM)IgG抗体水平升高,但尚不清楚HDM特异性IgG抗体的存在是否与哮喘的病因机制有关。为了解决这个问题,我们评估了一般儿科人群中HDM特异性IgG抗体水平与哮喘发生率之间的关系。通过RAST和ELISA检查了722名随机选择的学龄儿童的IgE和IgG抗体水平,其中包括26名哮喘患者,评估了该人群中相对于Df特异性的哮喘相对患病率IgE和IgG水平。哮喘的发病率不仅与Df特异性IgE水平相关,而且与Df特异性IgG水平相关。在总人群和哮喘儿童中,Df特异性IgE和IgG水平之间存在显着相关性。由于IgG和IgE反应在该人群中同时发生,因此HDM特异性IgG抗体的临床意义尚不清楚。但是,我们的发现表明,儿童哮喘的临床表达主要取决于其对HDM产生免疫应答的能力,其中包括IgE和IgG应答。

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