The search for the cause of transmissible spongiform encephalopathies (TSEs) has a long and tortuous history. In a recent paper, 25-nm virus-like particles were identified that were consistently observed in cell cultures infected with Creutzfeldt-Jakob disease (CJD) and scrapie; they are similar to, or even identical with, the virus-like tubulovesicular structures (TVS) found in experimental scrapie as early as in 1968, and subsequently in all naturally occurring and experimentally induced TSEs. These particles have been viewed with caution by the scientific community because of the unverified or uninterpretable record of virus-like structures reported over the years in TSEs. TVS are spherical or tubular particles of approximate diameter 25-37 nm. They are smaller than synaptic vesicles, but larger than many particulate structures of the central nervous system, such as glycogen granules. Their electron density is higher compared with synaptic vesicles, and in experimental murine scrapie, they form paracrystalline arrays. None of these observations distinguish between TVS as an entity critical to the infectious process, or as a highly specific ultrastructural epiphenomenon, but their consistent presence in all TSEs demands further research.

译文

寻找可传播的海绵状脑病 (TSEs) 的原因有着悠久而曲折的历史。在最近的一篇论文中,鉴定出25纳米病毒样颗粒,这些颗粒在感染克雅氏病 (CJD) 和瘙痒病的细胞培养物中一致观察到; 它们与,早在1968年就在实验性瘙痒病中发现了病毒样小管结构 (TVS),随后在所有自然发生和实验诱导的TSEs中发现。由于多年来在TSEs中报告的病毒样结构未经验证或无法解释的记录,因此科学界对这些粒子持谨慎态度。TVS是直径约为25-37 nm的球形或管状颗粒。它们比突触小泡小,但比中枢神经系统的许多颗粒结构 (如糖原颗粒) 大。与突触小泡相比,它们的电子密度更高,并且在实验性鼠瘙痒病中,它们形成了副晶体阵列。这些观察结果都没有区分TVS是对感染过程至关重要的实体,还是高度特定的超微结构现象,但是它们在所有TSEs中的一致存在需要进一步研究。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录