BACKGROUND:Cervical cancer, a leading cause of cancer deaths in women in developing countries can be prevented primarily by vaccinating adolescent girls and women against infection by the human papillomavirus (HPV) before their first sexual exposure, and secondarily through screening and treatment of identified precancerous lesions. AIM:To determine the awareness and acceptability of the HPV vaccine and screening for cervical cancer among female health-care workers in Enugu, southeastern Nigeria. MATERIALS AND METHODS:Questionnaires were administered to a cross-section of 177 female health-care workers selected systematically from the University of Nigeria Teaching Hospital (UNTH), Enugu, Nigeria. Statistical analysis was both descriptive and inferential at 95% confidence level using the Statistical Package for Social Sciences (SPSS) computer software version 16. A P value of less than 0.05 was considered statistically significant. RESULTS:The awareness of screening for cervical cancer (91%) was significantly higher than that of the HPV vaccine (62.7%) [odds ratio (OR): 0.17; 95% confidence interval (CI): 0.09-0.30]. However, the acceptability rate of the HPV vaccine (91.0%) was significantly higher than that of cervical screening (71.4%) (OR: 4.04;95% CI: 1.94-8.42)]. Only 25 (14.1%) of the health-care workers had done cervical screening, but 30 (49.2%) of the 61 respondents with adolescent daughters had immunized their daughters with the HPV vaccine. Although no reason was given for the low participation in cervical screening, cost and availability of HPV vaccine was a major deterrent for the latter. CONCLUSION:With more public enlightenment, available and affordable HPV vaccine appears to hold the key for prevention of cervical cancer in developing countries where the burden is high.

译文

背景:宫颈癌是发展中国家女性癌症死亡的主要原因,可以通过以下方法来预防:首先通过对青春期的女孩和妇女进行首次性接触前的人乳头瘤病毒(HPV)疫苗接种,然后再通过筛查和治疗已确定的癌前癌症来预防宫颈癌病变。
目的:确定尼日利亚东南部恩古格(Enugu)的女性卫生保健工作者对HPV疫苗的认识和接受程度以及宫颈癌的筛查。
材料与方法:对从尼日利亚埃努古的尼日利亚大学教学医院(UNTH)系统地选出的177名女性卫生保健工作者进行了问卷调查。使用统计软件包(SPSS)计算机软件版本16进行的统计分析在95%置信水平下具有描述性和推断性。P值小于0.05被认为具有统计学意义。
结果:对宫颈癌的筛查意识(91%)明显高于对HPV疫苗的筛查意识(62.7%)[几率(OR):0.17; 95%置信区间(CI):0.09-0.30]。但是,HPV疫苗的可接受率(91.0%)显着高于宫颈筛查的可接受率(71.4%)(OR:4.04; 95%CI:1.94-8.42)]。仅有25名(14.1%)的卫生保健工作者进行了宫颈筛查,但在61名有青春期女儿的受访者中,有30名(49.2%)对其女儿进行了HPV疫苗免疫。尽管没有理由不参与宫颈筛查,但HPV疫苗的成本和可获得性是后者的主要威慑力量。
结论:随着公众的启发,可用的和负担得起的HPV疫苗似乎是负担高的发展中国家预防子宫颈癌的关键。

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