OBJECTIVE:The prevalence of cervical cancer and high-risk human papillomavirus (HPV) in Nigerian women remains poorly studied. Our objective was to estimate the prevalence of high-risk HPV and associated squamous intraepithelial lesions (SILs) in Nigeria. METHODS:After institutional review board approval, data collection was performed by volunteers of FaithCare, Inc, between 2004 and 2008 in 3 regions of Nigeria (Okene, Katari, and Abuja). Demographic data and ThinPrep Pap smears (Cytyc, Marlborough, MA) were collected from 410 women. Pap smears were analyzed for both the presence of SIL and HPV DNA. RESULTS:The prevalence of high-risk HPV and SIL was 15.6% and 6.8%, respectively. Of the 28 abnormal Pap tests, 42.9% had atypical squamous cells of undetermined significance, 39.3% had low-grade SIL, 14.3% had high-grade SIL, and 3.6% had atypical glandular cells. There was a strong association between high-risk HPV and SIL in both the combined (p < .001) and individual group data (p < .001, p = .013, and p < .001 for Okene, Abuja, and Katari, respectively). However, there were no statistically significant correlations between either high-risk HPV or presence of SIL and known risk factors including age, history of sexually transmitted disease, and the number of sexual partners. There was also no statistical difference in the prevalence of high-risk HPV and SIL among the 3 locations. CONCLUSIONS:A strong association exists between high-risk HPV and SIL. The prevalence of cervical high-risk HPV and SIL, however, did not vary in the 3 different locations and is consistent with reports from other regions in Africa.

译文

目的:在尼日利亚妇女中宫颈癌和高危人类乳头瘤病毒(HPV)的患病率仍缺乏研究。我们的目标是评估尼日利亚的高危HPV和相关的鳞状上皮内病变(SILs)的患病率。
方法:经过机构审查委员会的批准,FaithCare,Inc的志愿者在2004年至2008年之间在尼日利亚的三个地区(Okene,Katari和Abuja)进行了数据收集。收集了410位妇女的人口统计学数据和ThinPrep子宫颈抹片检查(Cytyc,Marlborough,MA)。分析宫颈涂片是否存在SIL和HPV DNA。
结果:高危HPV和SIL的患病率分别为15.6%和6.8%。在28项异常的巴氏试验中,有42.9%的非典型鳞状细胞具有未确定的意义,39.3%的低度SIL,14.3%的高度SIL和3.6%的非典型腺细胞。高风险HPV和SIL在合并数据(p <.001)和单个组数据(p <.001,p = .013,对于Okene,Abuja和Katari的p <.001,两者之间都有很强的关联,分别)。但是,高风险的HPV或SIL的存在与已知的风险因素(包括年龄,性传播疾病的病史和性伴侣的数量)之间没有统计学上的显着相关性。在这三个地点之间,高危HPV和SIL的患病率也没有统计学差异。
结论:高危HPV与SIL之间存在很强的联系。然而,宫颈高危型HPV和SIL的患病率在3个不同地区没有变化,与非洲其他地区的报告一致。

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