Osteoporosis is characterized by low bone mass and by changes in the microarchitecture of the bone. This leads to reduced bone stability and altered suscebtibility to fractures. Bone remodelling in healthy persons is characterized by a balance between bone resorption and bone formation. At the cellular level, bone remodelling is regulated by osteoclast and osteoblast activity. During bone loss, there is an imbalance, osteoclast activity being more pronounced. Therefore, the influende of estrogens, Wnt and the RANK/ RANKL/OPG system on osteoclastogenesis and osteoclast activity has been investigated. The RANK/RANKL/OPG-System is actively involved in the differentiation and function of osteoclasts and seems to play a central part in most pathophysiological mechanisms that are active in osteoporosis.

译文

:骨质疏松症的特征是骨量低和骨骼的微结构改变。这会导致骨骼稳定性下降和骨折易感性改变。健康人的骨骼重塑的特征是骨骼吸收与骨骼形成之间的平衡。在细胞水平上,骨重塑受破骨细胞和成骨细胞活性的调节。在骨质流失期间,会出现失衡,破骨细胞的活动会更加明显。因此,已经研究了雌激素,Wnt和RANK / RANKL / OPG系统对破骨细胞生成和破骨细胞活性的影响。 RANK / RANKL / OPG系统积极参与破骨细胞的分化和功能,似乎在活跃于骨质疏松症的大多数病理生理机制中发挥着核心作用。

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