BACKGROUND:Squamous cell carcinoma of the head and neck (HNSCC) represents an array of disease processes with a generally unfavorable prognosis. Inflammation plays an important role in tumor development and response to therapy. We performed a retrospective analysis of HNSCC patients to explore the relationship of the lymphocyte and neutrophil counts, the neutrophil-to-lymphocyte ratio (NLR) overall survival (OS), cancer-specific survival (CSS), local control (LC) and distant control (DC). MATERIALS/METHODS:All patients received definitive treatment for cancers of the oropharynx or larynx between 2006-2015. Neutrophil and lymphocyte counts were collected pre-, during-, and post-treatment. The correlations of patient, tumor, and biological factors to OS, CSS, LC and DC were assessed. RESULTS:196 patients met our inclusion criteria; 171 patients were Stage III or IV. Median follow-up was 2.7 years. A higher neutrophil count at all treatment time points was predictive of poor OS with the pre-treatment neutrophil count and overall neutrophil nadir additionally predictive of DC. Higher pre-treatment and overall NLR correlated to worse OS and DC, respectively. CONCLUSION:A higher pre-treatment neutrophil count correlates to poor OS, CSS and DC. Lymphocyte counts were not found to impact survival or tumor control. Higher pre-treatment NLR is prognostic of poor OS.

译文

背景:头颈部鳞状细胞癌(HNSCC)代表了一系列疾病过程,通常预后不良。炎症在肿瘤发展和对治疗的反应中起重要作用。我们对HNSCC患者进行了回顾性分析,以探讨淋巴细胞与嗜中性粒细胞计数,嗜中性粒细胞与淋巴细胞之比(NLR)总体生存率(OS),癌症特异性生存率(CSS),局部对照(LC)和远处的关系控制(DC)。
材料/方法:2006-2015年间,所有患者均接受了针对口咽或喉癌的明确治疗。在治疗前,治疗中和治疗后收集中性粒细胞和淋巴细胞计数。评估了患者,肿瘤和生物学因素与OS,CSS,LC和DC的相关性。
结果:196例患者符合我们的纳入标准; 171例患者处于III期或IV期。中位随访时间为2.7年。在所有治疗时间点,中性粒细胞计数较高可预示OS较差,而治疗前中性粒细胞计数和总中性粒细胞最低值可预测DC。较高的预处理和总体NLR分别与较差的OS和DC有关。
结论:治疗前中性粒细胞计数升高与OS,CSS和DC差有关。未发现淋巴细胞计数影响存活或肿瘤控制。较高的治疗前NLR预后不良。

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