Superoxide production by neutrophils triggered with a chemotactic peptide or a phorbol ester is inhibited by the protein kinase antagonists staurosporine or 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7). We evaluated the effects of these antagonists on the protein tyrosine kinases and protein kinase C activities of neutrophils. Staurosporine completely inhibited all of these enzymes, whereas 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine was only substantially effective against protein kinase C. Thus, if a protein tyrosine kinase is involved in superoxide production, it is likely to function with a second kinase sensitive to 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine.

译文

:由趋化肽或佛波醇酯触发的嗜中性粒细胞产生的超氧化物被蛋白激酶拮抗剂星形孢菌素或1-(5-异喹啉基磺酰基)-2-甲基哌嗪(H-7)抑制。我们评估了这些拮抗剂对嗜中性粒细胞蛋白酪氨酸激酶和蛋白激酶C活性的影响。星形孢菌素完全抑制所有这些酶,而1-(5-异喹啉基磺酰基)-2-甲基哌嗪仅对蛋白质激酶C有效。对1-(5-异喹啉基磺酰基)-2-甲基哌嗪敏感的激酶。

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