This issue of the British Journal of Pharmacology is dedicated to reviews of the major animal models used in neuropharmacology to examine drugs for both neurological and psychiatric conditions. Almost all major conditions are reviewed. In general, regulatory authorities require evidence for the efficacy of novel compounds in appropriate animal models. However, the failure of many compounds in clinical trials following clear demonstration of efficacy in animal models has called into question both the value of the models and the discovery process in general. These matters are expertly reviewed in this issue and proposals for better models outlined. In this editorial, we further suggest that more attention be made to incorporate pharmacokinetic knowledge into the studies (quantitative pharmacology). We also suggest that more attention be made to ensure that full methodological details are published and recommend that journals should be more amenable to publishing negative data. Finally, we propose that new approaches must be used in drug discovery so that preclinical studies become more reflective of the clinical situation, and studies using animal models mimic the anticipated design of studies to be performed in humans, as closely as possible.

译文

:本期《英国药理学杂志》(British Journal of Pharmacology)致力于研究神经药理学中用于检查神经和精神疾病的药物的主要动物模型。几乎所有主要条件都经过审查。通常,监管机构要求在适当的动物模型中提供有关新化合物功效的证据。然而,在清楚地证明了动物模型中的功效之后,许多化合物在临床试验中的失败使人们对模型的价值和一般的发现过程都产生了疑问。本期将对这些问题进行专家审查,并概述更好的模型的建议。在这篇社论中,我们进一步建议将更多的药代动力学知识纳入研究(定量药理学)。我们还建议更加注意确保发布完整的方法学详细信息,并建议期刊应更适合发布负面数据。最后,我们建议在药物开发中必须使用新方法,以使临床前研究更能反映临床情况,并且使用动物模型进行的研究尽可能模仿拟在人体中进行的预期研究设计。

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