The zebrafish (Danio rerio) is increasingly utilized as a powerful new model organism in neurobehavioral research. Aggression is a common symptom of many CNS disorders, has some genetic determinants and can be modulated pharmacologically in humans and animal model species. Mounting evidence suggests zebrafish as a useful tool to study neurobiology of aggression, and its pharmacological and genetic regulation. Here, we discuss mechanisms of zebrafish aggression and their pharmacological, pharmacogenetic and pharmacogenomic models, as well as recent developments and existing challenges in this field. We also emphasize the growing utility of zebrafish models in translational neuropharmacological research of aggression, fostering future discoveries of potential therapeutic agents for aggressive behavior.

译文

斑马鱼(Danio rerio)在神经行为研究中被越来越多地用作一种强大的新型生物体。侵略性是许多中枢神经系统疾病的常见症状,具有一些遗传决定因素,可以在人和动物模型物种中进行药理调节。越来越多的证据表明,斑马鱼是研究侵略性神经生物学及其药理和遗传调控的有用工具。在这里,我们讨论了斑马鱼的攻击机制及其药理,药理遗传和药物基因组学模型,以及该领域的最新发展和存在的挑战。我们还强调了斑马鱼模型在侵略性转化神经药理学研究中的实用性不断增强,促进了对攻击性行为的潜在治疗剂的未来发现。

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