Exposure to drugs early in life can have long-lasting implications for brain structure and function. Effects on the developing nervous system, before homeostatic regulatory mechanisms are properly calibrated, differ from those on mature systems. Recent studies show that permanent alterations in brain pharmacology and cell signaling are induced by early drug exposure, producing hypo- or hyperresponsiveness to environmental or pharmacological challenges later in life. As a result, children exposed to drugs pre- or postnatally might respond abnormally to therapeutics used to treat the very disorders that they later exhibit as a result of their previous drug exposure.

译文

:在生命早期接触药物会对大脑的结构和功能产生长期影响。在正确调节稳态调节机制之前,对发育中的神经系统的影响与对成熟系统的影响不同。最近的研究表明,早期药物暴露会引起脑部药理学和细胞信号的永久改变,从而对生命后期的环境或药理学挑战产生反应不足或反应过度。结果,在产前或产后接触药物的儿童可能会对用于治疗由于后来的先前药物暴露而后来表现出的疾病的疗法产生异常反应。

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