Human prion diseases, in common with other neurodegenerative diseases, may be sporadic or inherited and are characterized by the accumulation of cellular proteins accompanied by neuronal death and synaptic loss. Prion diseases are, however, unique in being transmissible. Central to the pathogenesis of all forms of prion disease is the prion protein. This article provides a brief overview of the biology of human prion diseases followed by a more in-depth discussion of the neuropathology of these diseases, including features of neuroradiologic relevance.

译文

人pr病毒疾病与其他神经退行性疾病相同,可能是散发性或遗传性疾病,其特征是细胞蛋白蓄积,伴有神经元死亡和突触丧失。然而,病毒是可以传播的独特疾病。 forms病毒蛋白是所有形式的pr病毒病发病机制的核心。本文简要介绍了人类病毒疾病的生物学特性,然后更深入地讨论了这些疾病的神经病理学,包括神经放射学相关性的特征。

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