Sirtuins (SIRTs) are a family of regulatory proteins of genetic information with a high degree of conservation among species. The SIRTs are heavily involved in several physiological functions including control of gene expression, metabolism, and aging. SIRT1 has been the most studied sirtuin and plays important role in the prevention and progression of neurodegenerative diseases acting in different pathways of proteins involved in brain function. SIRT1 activation regulates important genes that also exert neuroprotective actions such as p53, nuclear factor kappa B, peroxisome proliferator-activated receptor-gamma (PPARγ), PPARγ coactivator-1α, liver X receptor, and forkhead box O. It is well established in literature that growing population aging, oxidative stress, inflammation, and genetic factors are important conditions to development of neurodegenerative disorders. However, the exact pathophysiological mechanisms leading to these diseases remain obscure. The sirtuins show strong potential to become valuable predictive and prognostic markers for diseases and as therapeutic targets for the treatment of a variety of neurodegenerative disorders. In this context, the aim of the current review is to present an actual view of the potential role of SIRT1 in modulating the interaction between target genes and neurodegenerative diseases on the brain.

译文

:Sirtuins(SIRTs)是遗传信息的调节蛋白家族,在物种间具有高度的保守性。 SIRTs大量参与多种生理功能,包括基因表达,代谢和衰老的控制。 SIRT1是研究最深入的sirtuin,在神经退行性疾病的预防和发展中起着重要作用,神经退行性疾病通过参与大脑功能的蛋白质的不同途径起作用。 SIRT1激活调节重要基因,这些重要基因也发挥神经保护作用,例如p53,核因子kappa B,过氧化物酶体增殖物激活受体-γ(PPARγ),PPARγcoactivator-1α,肝脏X受体和前叉箱O。不断增长的人口老龄化,氧化应激,炎症和遗传因素是神经退行性疾病发展的重要条件。但是,导致这些疾病的确切病理生理机制仍然不清楚。 sirtuins具有强大的潜力,可成为疾病的有价值的预测和预后标志物,并可作为治疗各种神经退行性疾病的治疗靶标。在这种情况下,本综述的目的是提出SIRT1在调节靶基因与大脑神经退行性疾病之间相互作用中的潜在作用的实际观点。

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