Neurodegenerative diseases encompass complex cell signaling disturbances that initially damage neuronal circuits and synapses. Due to multiple protective mechanisms enacted to counteract the onset of neurodegenerative diseases, there is often a prolonged period without noticeable impairments during their initiation. Since severe cognitive deficit or vision loss takes place after that period there is an opportunity to harness endogenous protective mechanisms as potential therapeutic approaches. The activation of the biosynthesis of the docosanoid mediator neuroprotectin D1 (NPD1) is an early response to the upsurge of protein misfolding and other neuroinflammatory events. This overview discusses the potent neuroprotective and inflammation-modulating bioactivity of NPD1. This lipid mediator represents an early response to neurodegenerations, aiming to restore homeostasis.

译文

神经退行性疾病包括复杂的细胞信号传导障碍,最初会破坏神经元回路和突触。由于采取了多种保护机制来抵消神经退行性疾病的发作,因此通常有一段较长的时期,而在其启动过程中却没有明显的损害。由于在此期间之后发生严重的认知缺陷或视力丧失,因此有机会利用内源性保护机制作为潜在的治疗方法。 docosanoid介质神经保护素D1(NPD1)的生物合成的激活是对蛋白质错误折叠和其他神经炎性事件激增的早期反应。此概述讨论了NPD1的强大的神经保护和炎症调节生物活性。这种脂质介体代表对神经变性的早期反应,旨在恢复体内平衡。

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