A dietary supply of docosahexaenoic acid (DHA, 22:6n-3) during the perinatal period is postulated to be important for the neurodevelopmental outcome of children. This paper reviews the results of two large scale intervention trials in which equivalent dietary doses of DHA were assessed. One trial assessed the ex utero effect of DHA supplementation for preterm infants born <33 weeks' gestation while the other trial assessed the in utero effect of DHA supplementation during the second half of pregnancy. Ex utero DHA supplementation, which aimed to achieve the level of DHA accumulation that would occur in the womb, appeared more effective in improving the neurodevelopmental outcome of preterm children rather than in utero DHA supplementation of unborn infants. Significant treatment by sex and treatment by birth weight interactions were noted indicating that boys and girls respond differently to DHA supplementation and that birth weight may also be important in predicating the DHA responsiveness.

译文

:围产期饮食中二十二碳六烯酸的饮食供应(DHA,22:6n-3)被认为对儿童的神经发育结局很重要。本文回顾了两项大型干预试验的结果,其中评估了等效饮食剂量的DHA。一项试验评估了补充DHA对妊娠小于33周出生的早产儿的宫内作用,而另一项试验评估了补充DHA在怀孕后半期的宫内作用。旨在达到子宫中DHA积累水平的Exutero DHA补充剂在改善早产儿神经发育结局方面比在未出生婴儿的子宫DHA补充剂中更有效。注意到通过性别和出生体重相互作用进行的重要治疗,表明男孩和女孩对补充DHA的反应不同,出生体重在预测DHA反应性方面也可能很重要。

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