Alzheimer's disease (AD) is a progressive neurodegenerative disorder that shows cognitive deficits and memory impairment. Extract from the leaves of Gotu Kola (Centella Asiatica) have been used as an alternative medicine for memory improvement in Indian Ayurvedic system of medicine for a long time. Although several studies have revealed its effect in ameliorating the cognitive impairment in rat models of AD and stimulating property on neuronal dendrites of hippocampal region, the molecular mechanism of Gotu Kola on neuroprotection still remains to be elucidated. In this study, we report that phosphorylation of cyclic AMP response element binding protein (CREB) is enhanced in both a neuroblastoma cell line expressing amyloid beta 1-42 (Abeta) and in rat embryonic cortical primary cell culture. In addition, the contribution of two major single components to the enhanced CREB phosphorylatioin was examined. Furthermore, inhibitors were applied in this study revealing that ERK/RSK signaling pathway might mediate this effect of Gotu Kola extract. Taken together, we provide a possible molecular mechanism for memory enhancing property of Gotu Kola extract for the first time.

译文

:阿尔茨海默氏病(AD)是一种进行性神经退行性疾病,表现出认知缺陷和记忆障碍。很长一段时间以来,从印度洋草药的叶子中提取出的Gotu Kola(积雪草)叶子的提取物已被用作改善记忆的替代药物。尽管一些研究已经揭示了其在减轻AD模型大鼠认知障碍和刺激海马区神经元树突特性方面的作用,但Gotu Kola对神经保护的分子机制仍有待阐明。在这项研究中,我们报告说,环状AMP反应元件结合蛋白(CREB)的磷酸化在表达淀粉样蛋白1-1-4(Abeta)的成神经母细胞瘤细胞系和大鼠胚胎皮层原代细胞培养物中均得到增强。另外,检查了两种主要的单一组分对增强的CREB磷酸化的贡献。此外,在该研究中应用了抑制剂,揭示了ERK / RSK信号传导途径可能介导了Gotu Kola提取物的这种作用。两者合计,我们首次提供了一种可能的分子机制,以增强Gotu Kola提取物的记忆力。

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