We used functional MRI (fMRI) to study the aging influence on functional connectivity of the motor network in the resting state. A network model based on graph theory was used to measure functional connectivity. The total connectivity degree of each region within the motor network was calculated and compared between aged and young groups. We found that the pattern of functional connectivity was changed in aged subjects, including a significant decrease in the functional connectivity degree of the right cingulate motor area and left premotor area compared to young subjects. Our study demonstrates that normal aging modulates the functional connectivity of motor network in the resting state. We postulate that this abnormal functional connectivity of motor network in the baseline state is an important reason contributing to the deteriorated motor ability in aged subjects.

译文

:我们使用功能性MRI(fMRI)来研究衰老对静止状态下运动网络功能连接的影响。使用基于图论的网络模型来测量功能连通性。计算了电动机网络内每个区域的总连接度,并比较了老年和青年组。我们发现,在老年受试者中,功能连接的模式发生了变化,包括与年轻受试者相比,右侧扣带回运动区和左侧运动前区的功能连接度显着降低。我们的研究表明,正常老化会在静止状态下调节电机网络的功能连通性。我们假设在基线状态下这种运动网络的异常功能连通性是导致老年受试者运动能力下降的重要原因。

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