In the nineteenth century, there was a continuous debate on the structure and function of the brain, focusing on localization of function and on epilepsy. France, Germany, and England played a leading role. This article addresses the question of what happened with respect to the study of epilepsy in the Netherlands in that period. A systematic search of the literature has been performed and papers by Schroeder van der Kolk, Huet, Jelgersma, and Niermeijer are discussed. Also two dissertations were selected for discussion, those of Kroon and Langelaan. It is concluded that from a scientific point of view, only the paper by Schroeder van der Kolk deserved and received international attention.