Many case reports have indicated the occurrence of monoclonal gammopathy of uncertain significance (MGUS) or multiple myeloma (MM) in patients with Ph-negative myeloproliferative neoplasms (MPN), but few cohorts of patients have been published. This study concerns 667 patients newly diagnosed with polycythemia vera (PV) or essential thrombocythemia (ET) who were tested for monoclonal (M) protein at diagnosis (13.9% of patients). The overall survival of patients with M protein was dramatically lower than that of patients without M protein (12.7 versus 22.4 years; p = .0132). Univariate analysis identified the presence of M protein as a potential risk factor for the secondary occurrence of myelofibrosis (p = .02), myelodysplastic syndrome (p = .043), and MM/Waldenstrom macroglobulinemia (p < .0001). Our cohort shows that the presence of M proteins in patients with PV or ET leads to a poor prognosis. We believe that testing for M protein could help practicians to identify such patients.

译文

:许多病例报告表明,在Ph阴性骨髓增生性肿瘤(MPN)患者中发生了意义不明的单克隆丙种球蛋白病(MGUS)或多发性骨髓瘤(MM),但很少有患者队列发表。这项研究涉及667名新诊断为真性红细胞增多症(PV)或原发性血小板增多症(ET)的患者,他们在诊断时接受了单克隆(M)蛋白测试(占患者的13.9%)。有M蛋白的患者的总生存率显着低于无M蛋白的患者(分别为12.7年和22.4年; p = 0.132)。单因素分析确定M蛋白的存在是继发性骨髓纤维化(p = .02),骨髓增生异常综合症(p = .043)和MM / Waldenstrom巨球蛋白血症(p <.0001)的潜在危险因素。我们的队列研究表明,PV或ET患者中M蛋白的存在会导致预后不良。我们认为对M蛋白的检测可以帮助从业人员识别此类患者。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录