In this study serum cholesterol was measured in different types of human hematologic malignancies characterized by a wide range of cell proliferation. In all tumoral types a significant decrease of HDL cholesterol was observed, whereas total serum cholesterol generally remained unchanged. Another interesting observation of our study was the apparent inverse correlation between the extent of cell proliferation in these neoplastic disorders and the level of HDL cholesterol. Since a decrease of HDL cholesterol was previously observed, in our laboratory, in different experimental models of normal and neoplastic cell proliferation, we suggest that the decrease of HDL cholesterol may be a generalized phenomenon related to massive cellular growth in normal and malignant processes.

译文

:在这项研究中,以各种细胞增殖为特征的不同类型的人类血液系统恶性肿瘤中的血清胆固醇水平得到了测定。在所有肿瘤类型中,均观察到HDL胆固醇显着降低,而总血清胆固醇通常保持不变。我们研究的另一个有趣观察结果是这些肿瘤性疾病中细胞增殖程度与HDL胆固醇水平之间呈明显负相关。由于以前曾观察到HDL胆固醇降低,因此在我们的实验室中,正常和肿瘤细胞增殖的不同实验模型中,我们建议HDL胆固醇降低可能是与正常和恶性过程中大量细胞生长有关的普遍现象。

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