The annual rate of Down syndrome (DS) births in Jerusalem is stable, regardless of prenatal screening, and diagnostic measures. We aimed to evaluate our historical cohort for obstetrical characteristics and the neonatal course and complications. We reviewed computerized medical files of neonates with the diagnosis of DS born in the four main hospitals in Jerusalem between the years 2000 and 2010 and evaluated for maternal history and primary neonatal hospitalization. A total of 403 neonates were diagnosed with DS. The average maternal age was 35.6 years, 73% were born via spontaneous vaginal delivery. In all gestational ages, the mean birth weight and head circumference percentiles were significantly lower than the general population (P < 0.001 for both) and at each week the HC percentile was lower than the weight percentile (P < 0.0001), worse among males. Mortality during the primary hospitalization was 3.7%. The most common anomalies were cardiac (79%) with either congenital defects or functional abnormalities, neither influenced the length of hospitalization. The main reasons for prolonged hospitalization were prematurity and anomalies of other (non-cardiac) organs. Common perinatal complications included respiratory failure or need for oxygen supplementation (32%), hyperbilirubinemia (23%), sepsis (6.4%), and feeding difficulties (13%). About 84% were fed by human milk; of those, two thirds were exclusively breast-fed and one third were supplemented with infant formula. In conclusion, infants with DS were small for gestational age with relatively reduced head circumference. Despite the increased rate of congenital anomalies and perinatal complications, most infants were discharged home in good medical condition and were exclusively breastfed.

译文

:无论进行产前筛查和诊断措施如何,耶路撒冷的唐氏综合症(DS)的年均出生率稳定。我们旨在评估我们的历史队列的产科特征,新生儿病程和并发症。我们回顾了2000年至2010年间在耶路撒冷四家主要医院出生的诊断为DS的新生儿的计算机病历,并评估了其母亲史和原发性新生儿住院治疗。共有403名新生儿被诊断患有DS。平均产妇年龄为35.6岁,其中73%是通过自然阴道分娩出生的。在所有胎龄儿,平均出生体重和头围百分位数均显着低于普通人群(两者均P <0.001),并且每周的HC百分位数均低于体重百分数(P <10.0001),在男性中更差。初次住院期间的死亡率为3.7%。最常见的异常是心脏病(79%),先天性缺陷或功能异常,均未影响住院时间。长期住院的主要原因是早产和其他(非心脏)器官异常。围产期常见的并发症包括呼吸衰竭或需要补充氧气(32%),高胆红素血症(23%),败血症(6.4%)和进食困难(13%)。约84%的人是用牛奶喂养的;其中,三分之二是纯母乳喂养的,三分之一则是婴儿配方奶粉的补充。总之,DS婴儿的胎龄较小,头围相对减少。尽管先天异常和围产期并发症的发生率增加,但大多数婴儿在良好的医疗条件下已出院回家,并且仅接受母乳喂养。

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