We evaluated the differences in strength of the associations of prevalent cardiovascular disease and lower extremity arterial atherosclerosis to common carotid intima-media thickness, assessed by near wall measurements only, by far wall measurements only, and by the average of near and far wall measurements. The study was based on data from 1500 participants of the Rotterdam Study, a single-center-population-based prospective follow-up study among 7983 subjects, aged 55 years or over. Comparison of the strength of the associations of near wall intima-media thickness and of combined near and far wall intima-media thickness to cardiovascular disease and lower extremity arterial atherosclerosis revealed significantly stronger associations compared to associations observed for far wall intima-media thickness, in particular for stroke and lower extremity arterial disease. We conclude that near wall common carotid intima-media thickness measurement provides at least as good an indicator of atherosclerosis elsewhere and of cardiovascular risk as the far wall intima-media thickness measurement.

译文

:我们评估了常见心血管疾病和下肢动脉粥样硬化与颈总动脉内膜中层厚度之间的关联强度差异,仅通过近壁测量,仅远壁测量以及近壁和远壁测量的平均值来评估。该研究基于来自鹿特丹研究的1500名参与者的数据,鹿特丹研究是一项基于单中心人群的前瞻性随访研究,涉及对象为7983名年龄在55岁以上的受试者。比较近壁内膜-中层厚度和近,远壁内膜-中层厚度联合对心血管疾病和下肢动脉粥样硬化的强度,发现与远壁内膜-中层厚度相关的关联明显更强。特别适用于中风和下肢动脉疾病。我们得出的结论是,近壁普通颈动脉内膜中层厚度测量至少可以提供与远壁内膜中层厚度测量一样好的动脉粥样硬化和心血管风险的指标。

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