Objective: A cognitive neuroscience perspective seeks to understand behavior, in this case the comorbidity of cannabis abuse and conduct disorder/conduct problems, in terms of dysfunction in cognitive processes underpinned by neural processes. The goal of this review is to articulate a cognitive neuroscience account of this comorbidity. Methods: Literature on the following issues will be reviewed: (i) the longitudinal relationship between cannabis abuse and conduct disorder/conduct problems (CD/CP); (ii) the extent to which there are genetic and environmental (specifically maltreatment) factors that underpin this relationship; (iii) forms of neurocognitive function that are reported dysfunctional in CD/CP and also, when dysfunctional, appear to be risk factors for future cannabis abuse; and (iv) the extent to which cannabis abuse may further compromise these systems leading to increased future abuse and greater conduct problems. Results: CD/CP typically predate cannabis abuse. There appear to be shared genetic factors that contribute to the relationship between CD/CP and cannabis abuse. Moreover, trauma exposure increases risk for both cannabis abuse and CP/CD. One form of neurocognitive dysfunction, response disinhibition, that likely exacerbates the symptomatology of many individuals with CD also appears to increase the risk for cannabis abuse. The literature with respect to other forms of neurocognitive dysfunction remains inconclusive. Conclusions: Based on the literature, a causal model of the comorbidity of cannabis abuse and CD/CP is developed.

译文

:目的:认知神经科学的观点旨在了解行为,在这种情况下是滥用大麻和行为/行为问题的合并症,涉及以神经过程为基础的认知过程中的功能障碍。这篇综述的目的是阐明这种合并症的认知神经科学解释。方法:将审查有关以下问题的文献:(i)大麻滥用与行为障碍/品行问题(CD / CP)之间的纵向关系; (ii)遗传和环境(特别是虐待)因素在多大程度上支撑了这种关系; (iii)在CD / CP中据报告功能障碍的神经认知功能形式,以及当功能障碍时,也似乎是未来滥用大麻的危险因素; (iv)大麻滥用在多大程度上可能进一步损害这些系统,从而导致未来滥用和行为问题增加。结果:CD / CP通常早于大麻滥用。似乎存在共同的遗传因素,导致CD / CP与大麻滥用之间的关系。此外,遭受创伤会增加大麻滥用和CP / CD的风险。一种神经认知功能障碍,即反应抑制异常,可能加剧许多CD患者的症状,也似乎增加了滥用大麻的风险。关于其他形式的神经认知功能障碍的文献仍无定论。结论:根据文献,建立了大麻滥用与CD / CP合并症的因果模型。

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