Coronavirus disease 2019 (COVID-19) is an emerging pandemic disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although the majority of patients who become infected with SARS-CoV-2 are asymptomatic or have mild symptoms, some patients develop severe symptoms that can permanently detract from their quality of life. SARS-CoV-2 is closely related to SARS-CoV-1, which causes severe acute respiratory syndrome (SARS). Both viruses infect the respiratory system, and there are direct and indirect effects of this infection on multiple organ systems, including the musculoskeletal system. Epidemiological data from the SARS pandemic of 2002 to 2004 identified myalgias, muscle dysfunction, osteoporosis, and osteonecrosis as common sequelae in patients with moderate and severe forms of this disease. Early studies have indicated that there is also considerable musculoskeletal dysfunction in some patients with COVID-19, although long-term follow-up studies have not yet been conducted. The purpose of this article was to summarize the known musculoskeletal pathologies in patients with SARS or COVID-19 and to combine this with computational modeling and biochemical signaling studies to predict musculoskeletal cellular targets and long-term consequences of the SARS-CoV-2 infection.

译文

:冠状病毒病2019(COVID-19)是由严重的急性呼吸系统综合症冠状病毒2(SARS-CoV-2)引起的新兴大流行性疾病。尽管大多数感染SARS-CoV-2的患者无症状或症状较轻,但有些患者出现严重症状,可能永久性地降低其生活质量。 SARS-CoV-2与SARS-CoV-1密切相关,后者会导致严重的急性呼吸道综合症(SARS)。两种病毒都感染呼吸系统,并且这种感染对包括肌肉骨骼系统在内的多个器官系统都有直接或间接的影响。 2002年至2004年SARS大流行的流行病学数据将肌痛,肌肉功能障碍,骨质疏松和骨坏死定为中度和重度形式的该病患者的常见后遗症。早期研究表明,尽管尚未进行长期随访研究,但某些COVID-19患者也存在相当大的肌肉骨骼功能障碍。本文的目的是总结SARS或COVID-19患者的已知肌肉骨骼病理,并将其与计算模型和生化信号研究相结合,以预测肌肉骨骼细胞靶标和SARS-CoV-2感染的长期后果。

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