Programmed death-1 (PD-1), a member of the CD28 costimulatory receptor family, is expressed by germinal center-associated T cells in reactive lymphoid tissue. In a study of a wide range of lymphoproliferative disorders, neoplastic T cells in 23 cases of angioimmunoblastic lymphoma were immunoreactive for PD-1, but other subtypes of T cell and B cell non-Hodgkin lymphoma, as well as classic Hodgkin lymphoma, did not express PD-1. The pattern of PD-1 immunostaining of neoplastic cells in angioimmunoblastic lymphoma was similar to that reported for CD10, a recently described marker of neoplastic T cells in angioimmunoblastic lymphoma. Tumor-associated follicular dendritic cells in cases of angioimmunoblastic lymphoma were found to express PD-L1, the PD-1 ligand. In addition, PD-1-positive reactive T cells formed rosettes around neoplastic L&H cells in 14 cases of nodular lymphocyte predominant Hodgkin lymphoma studied. These findings, along with data from previous studies, suggest that angioimmunoblastic lymphoma is a neoplasm of germinal center-associated T cells and that there is an association of germinal center-associated T cells and neoplastic cells in nodular lymphocyte predominant Hodgkin lymphoma. PD-1 is a useful new marker for angioimmunoblastic lymphoma and lends further support to a model of T-cell lymphomagenesis in which specific subtypes of T cells may undergo neoplastic transformation and result in specific, distinct histologic, immunophenotypic, and clinical subtypes of T-cell neoplasia.

译文

程序性死亡-1 (PD-1) 是CD28共刺激受体家族的成员,由反应性淋巴组织中的生发中心相关T细胞表达。在一项广泛的淋巴增生性疾病的研究中,23例血管免疫母细胞淋巴瘤的肿瘤性T细胞对PD-1具有免疫反应性,但其他亚型的T细胞和b细胞非霍奇金淋巴瘤以及经典的霍奇金淋巴瘤均不表达PD-1。血管免疫母细胞淋巴瘤中肿瘤细胞的PD-1免疫染色模式与CD10的报道相似,CD10是最近描述的血管免疫母细胞淋巴瘤中肿瘤T细胞的标志物。在血管免疫母细胞淋巴瘤病例中,发现肿瘤相关滤泡树突状细胞表达PD-L1,即PD-1配体。此外,在研究的14例结节淋巴细胞为主的霍奇金淋巴瘤中,PD-1-positive反应性T细胞在肿瘤性L & H细胞周围形成了玫瑰花结。这些发现以及先前研究的数据表明,血管免疫母细胞性淋巴瘤是与生发中心相关的T细胞的肿瘤,并且在结节性淋巴细胞为主的霍奇金淋巴瘤中,生发中心相关的T细胞和肿瘤细胞存在关联。PD-1是血管免疫母细胞淋巴瘤的有用的新标记物,并为T细胞淋巴瘤发生模型提供了进一步的支持,在该模型中,T细胞的特定亚型可能经历肿瘤转化并导致T细胞瘤形成的特定,独特的组织学,免疫表型和临床亚型。

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