BACKGROUND & AIMS: :Thioredoxin-1 (TRX) is a small redox-active protein with antioxidative effects and redox-regulating functions. Cigarette smoking is a major etiological factor in the pathogenesis of a variety of diseases and recruits systemic immune and inflammatory responses. This report demonstrates that TRX attenuates the systemic inflammatory responses induced by cigarette smoking. The mRNA expressions of tumor necrosis factor alpha (TNF-alpha) and macrophage migration inhibitory factor (MIF) were suppressed in the spleen of TRX overexpressing transgenic mice (TRX-tg) exposed to cigarette smoking, compared with control C57BL/6 mice. In addition, protein carbonylation, a marker of cellular protein oxidation, was enhanced by cigarette smoking in the tissues of heart and liver in control mice more than in TRX-tg mice. These findings suggest that TRX may suppress the systemic inflammatory responses against cigarette smoking.

背景与目标： Thioredoxin-1 (TRX) 是一种小的氧化还原活性蛋白，具有抗氧化作用和氧化还原调节功能。吸烟是多种疾病发病的主要病因，并引发全身免疫和炎症反应。该报告表明TRX可以减轻吸烟引起的全身炎症反应。与对照组C57BL/6小鼠相比，吸烟时TRX过表达转基因小鼠 (TRX-tg) 脾脏中肿瘤坏死因子 α (TNF-α) 和巨噬细胞移动抑制因子 (MIF) 的mRNA表达受到抑制。此外，对照小鼠的心脏和肝脏组织中的吸烟比TRX-tg小鼠更多地增强了蛋白质羰基化，这是细胞蛋白质氧化的标志。这些发现表明，TRX可能会抑制针对吸烟的全身炎症反应。

BACKGROUND & AIMS: :As there are many conflicting sources of e-cigarette information, research is needed to determine the impact of these sources on e-cigarette attitudes to inform future communication campaigns. Source credibility is important in shaping attitudes toward other health topics; however, no study has examined its role in influencing e-cigarette attitudes. Data from the 2015 Health Information National Trends Survey-FDA (HINTS-FDA) were utilized to assess differences in trust in different sources by e-cigarette user status and to investigate the associations between trust in sources and e-cigarette attitudes (n = 3,738). Differences in trust in sources were examined using weighted linear regression. Associations between trust in sources of e-cigarette health effects and attitudes toward e-cigarettes were assessed using weighted logistic regression. Overall, e-cigarette ever users reported significantly lower trust in governmental agencies as compared to never users. Trust in e-cigarette companies was negatively associated with perceived addictiveness of e-cigarettes (AOR = 0.76, 95% CI = 0.58, 1.00), while trust in doctors/pharmacists/healthcare providers was negatively associated with harm perceptions of e-cigarettes relative to conventional cigarettes (AOR = 0.72, 95% CI = 0.55, 0.95). Trust in tobacco companies and trust in e-cigarette companies were negatively associated with absolute perceived harm of e-cigarettes (AOR = 0.70, 95% CI = 0.51, 0.95; AOR = 0.60, 95% CI = 0.46, 0.79, respectively). Results from this study indicate that the associations between trust in sources of e-cigarette health effects and e-cigarette attitudes differ both by source and specific attitude assessed. Ultimately, future campaigns should incorporate messaging to discredit industry sources of information and utilize non-governmental sources to effectively influence e-cigarette attitudes.

背景与目标： : 由于存在许多相互矛盾的电子烟信息来源，因此需要进行研究以确定这些来源对电子烟态度的影响，以为未来的交流活动提供信息。来源可信度对于塑造对其他健康主题的态度很重要; 但是，没有研究检查其在影响电子烟态度中的作用。来自2015健康信息国家趋势调查-FDA (HINTS-FDA) 的数据被用来评估电子烟用户状况对不同来源信任的差异，并调查来源信任与电子烟态度之间的关联 (n = 3,738)。使用加权线性回归检查来源信任的差异。使用加权逻辑回归评估了对电子烟健康影响来源的信任与对电子烟的态度之间的关联。总体而言，与从未使用过的电子烟用户相比，曾经使用过的电子烟用户对政府机构的信任度明显降低。对电子烟公司的信任与电子烟的感知成瘾性负相关 (AOR = 0.76，95% CI = 0.58，1.00)，而对医生/药剂师/医疗保健提供者的信任与电子烟相对于传统香烟的危害感知负相关 (AOR = 0.72，95% CI = 0.55，0.95)。对烟草公司的信任和对电子烟公司的信任与电子烟的绝对感知危害呈负相关 (AOR = 0.70，95% CI = 0.51，0.95; AOR = 0.60，95% CI = 0.46，0.79)。这项研究的结果表明，对电子烟健康影响来源的信任与电子烟态度之间的关联因来源和评估的特定态度而异。最终，未来的运动应纳入信息传递，以抹黑行业的信息来源，并利用非政府来源有效地影响电子烟的态度。

BACKGROUND & AIMS: :Gender-specific associations between prenatal smoking and birthweight, and neonate intensive health care were studied. Cross-sectional data from 11,583 newborns in the continuous National Health and Nutrition Examination Survey (NHANES) 2003-2008 early childhood data sets were used. Change in infant birthweight and likelihood of receiving neonatal intensive care by prenatal smoking exposure were assessed. Multivariable regression models were used to assess the influence of prenatal smoking on birthweight and likelihood of receiving intensive neonatal health care. Compared with infants from nonsmoking mothers, prenatal smoking associated with significant decrease in infant birthweight, -203.0 g ± 32.5, P < 0.001. The change in birthweight differed between infant boys, -220.2 g ± 44.5, and girls, -184.1 g ± 38.8. Newborns exposed to prenatal smoking were more likely to have low birthweight, odds ratio 1.46, P < 0.03, and to receive neonatal intensive health care, odds ratio 1.20; P < 0.04. It is imperative that prenatal counseling emphasizes prenatal maternal smoking.

背景与目标： : 研究了产前吸烟与出生体重之间的性别特异性关联，以及新生儿重症监护。使用了连续国家健康和营养检查调查 (NHANES) 2003-2008幼儿数据集中的11,583个新生儿的横断面数据。评估了婴儿出生体重的变化以及通过产前吸烟暴露接受新生儿重症监护的可能性。多变量回归模型用于评估产前吸烟对出生体重的影响以及接受重症新生儿保健的可能性。与非吸烟母亲的婴儿相比，产前吸烟与婴儿出生体重显着降低有关，-203.0g ± 32.5，P <0.001。婴儿男孩 (-220.2g ± 44.5) 和女孩 (-184.1g ± 38.8) 的出生体重变化不同。暴露于产前吸烟的新生儿更有可能出生体重低，比值比1.46，P <0.03，并接受新生儿重症监护，比值比1.20; P <0.04。产前咨询必须强调产前母亲吸烟。

BACKGROUND & AIMS: :Lung cancer is the leading cause of cancer-related mortality in both men and women throughout the world. This disease is strongly associated with tobacco smoking. The aim of this manuscript was to establish an in vitro model that mimics the chronic exposures of alveolar epithelial type II cells to the tobacco-specific nitrosamine carcinogen, NNK. Immortalized non-neoplastic alveolar epithelial cells type II, (E10 cells), from BALB/c mice were exposed to low concentration of NNK (100 pM) during 5, 10, 15, and 20 cycles of 48 h. NNK-transformed cells showed an increase of proliferation rate and motility. Moreover, these cells underwent epithelial-to-mesenchymal transition (EMT). Increased migratory capacity and EMT were correlated to the time of exposure to NNK. NNK-transformed cells were tested for their growth and metastatic capacity in vivo. Subcutaneous injection of cells exposed to NNK for 20 cycles (E10-NNK20 clone) into BALB/c mice led to the formation of subcutaneous tumors that arose after 40 ± 17 d in all animals, which died 95 ± 18 d after cell inoculation, with lymph nodes and lung metastasis. The morphological characteristics of tumors were compatible with metastatic undifferentiated carcinoma. Cells exposed to NNK for 5-10 cycles did not display metastatic capacity, while those exposed for 15 cycles displayed low capacity. Our results show that prolonged exposures to NNK led the cells to increasingly acquire malignant properties. The cellular model presented in this study is suitable for studying the molecular events involved in the different stages of malignant transformation.

背景与目标： : 肺癌是全世界男性和女性癌症相关死亡率的主要原因。这种疾病与吸烟密切相关。本手稿的目的是建立一个体外模型，该模型模拟肺泡上皮II型细胞对烟草特异性亚硝胺致癌物NNK的慢性暴露。来自BALB/c小鼠的永生化的非肿瘤性II型肺泡上皮细胞 (E10细胞) 在48  h的5、10、15和20个周期中暴露于低浓度的NNK (100  pM)。NNK转化的细胞显示出增殖速率和运动能力的增加。此外，这些细胞经历了上皮-间质转化 (EMT)。迁移能力和EMT的增加与NNK暴露时间相关。测试NNK转化的细胞在体内的生长和转移能力。在BALB/c小鼠中皮下注射暴露于NNK 20个周期的细胞 (E10-NNK20克隆) 导致所有动物皮下肿瘤的形成，该肿瘤在40  ±   17 d后出现，在细胞接种后95  ±   18 d死亡，并伴有淋巴结和肺转移。肿瘤的形态特征与转移性未分化癌相容。暴露于NNK 5-10个周期的细胞未显示转移能力，而暴露于15个周期的细胞显示低容量。我们的结果表明，长时间暴露于NNK导致细胞越来越多地获得恶性特性。本研究中提出的细胞模型适用于研究恶性转化不同阶段涉及的分子事件。

BACKGROUND & AIMS: BACKGROUND:This study sought to examine the relationship between tobacco-free policies at worksites to worksite demographics such as company size and geographic location. METHODS:Worksites participating in a worksite wellness workshop were asked to complete a worksite wellness instrument, which provided an assessment of their wellness practices already in place in the worksite, including the degree to which tobacco-free policies were in place at the worksite. RESULTS:At a bivariate level, those more likely to have tobacco-free policies included: urban employers (76.8% versus 50% rural employers, p = 0.0001); large employers (> = 250 employees) (74.3% versus 43.1% small employers (<50 employees), p = 0.0003); and schools (69.4%) and hospitals (61.5%) (versus 35.5%, agricultural/ manufacturing employers, p = 0.0125). At the multivariate level, rural employers (AOR = 0.47, 95% CI 0.23, 0.95) and small employers (AOR = 0.34, 95% CI 0.16, 0.71) had decreased odds, compared to their urban and large employer counterparts, of having tobacco-free policies. CONCLUSIONS:Rural and smaller employers are less likely to have tobacco-free policies than their urban and large counterparts.

背景与目标：

BACKGROUND & AIMS: AIM:To develop a simple and accurate method for quantifying 8-isoprostane in plasma by employing a combination of two-step solid-phase extraction of samples and a commercially available ELISA kit, and by this method to examine the effects of drinking and smoking habits against the levels of plasma 8-isoprostane in healthy Japanese volunteers. METHODS:Plasma 8-isoprostane was extracted with ODS gel suspension followed by NH(2) Sep-Pak column. The 8-isoprostane fractions were assayed using a commercially available ELISA kit. We measured plasma 8-isoprostane levels in 157 healthy Japanese volunteers divided into three groups (64 non-habitual drinkers, 56 moderate drinkers and 37 habitual drinkers) according to their alcohol consumption per week. Genotypes of aldehyde dehydrogenase 2 (ALDH2) were also determined to investigate the plasma 8-isoprostane levels with reference to drinking habits. In addition, the plasma 8-isoprostane levels of 96 non-smokers and 61 smokers from the same subjects were compared. RESULTS:Our method fulfilled all the requirements for use in routine clinical assays with respect to sensitivity, intra- and inter-assay reproducibility, accuracy and dynamic assay range. Significant increases of plasma 8-isoprostane levels were observed in female habitual drinkers when compared with those of non-habitual drinkers (t = 5.494, P<0.0001) as well as moderate drinkers (t = 3.542, P<0.005), and 8-isoprostane levels were also significantly different between ALDH2*2/1 and ALDH2*1/1 in the female habitual drinkers (t = 6.930, P<0.0001), suggesting that excessive drinking of alcohol may increase oxidization stress, especially in females. On the contrary, no significant difference of the plasma 8-isoprostane levels was observed between non-smokers and smokers. CONCLUSION:Our present method was proved to be a simple and accurate tool for measuring plasma 8-isoprostane. However, the clinical utility of plasma 8-isoprostane for drinking and smoking habits was limited since elevated 8-isoprostane levels were observed in female heavy drinkers, and no association was found between smokers and nonsmokers.

背景与目标：

BACKGROUND & AIMS: BACKGROUND:Health services and population health innovations advance when knowledge transfer and exchange (KTE) occurs among researchers, practitioners, policy-makers and consumers using high-quality evidence. However, few KTE models have been evaluated in practice. Communities of practice (CoP) - voluntary, self-organizing, and focused groups of individuals and organizations - may provide one option. This paper outlines an approach to lay the foundation for a CoP within the area of Web-assisted tobacco interventions (WATI). The objectives of the study were to provide a data-driven foundation to inform decisions about organizing a CoP within the geographically diverse, multi-disciplinary WATI group using evaluation and social network methodologies. METHODS:A single-group design was employed using a survey of expectations, knowledge, and interpersonal WATI-related relationships administered prior to a meeting of the WATI group followed by a 3-week post-meeting Web survey to assess short-term impact on learning and networking outcomes. RESULTS:Twenty-three of 27 WATI attendees (85%) from diverse disciplinary and practice backgrounds completed the baseline survey, with 21 (91%) of those participants completing the three-week follow-up. Participants had modest expectations of the meeting at baseline. A social network map produced from the data illustrated a centralized, yet sparse network comprising of interdisciplinary teams with little trans-sectoral collaboration. Three-week follow-up survey results showed that participants had made new network connections and had actively engaged in KTE activities with WATI members outside their original network. CONCLUSION:Data illustrating both the shape and size of the WATI network as well as member's interests and commitment to KTE, when shared and used to frame action steps, can positively influence the motivation to collaborate and create communities of practice. Guiding KTE planning through blending data and theory can create more informed transdisciplinary and trans-sectoral collaboration environments.

背景与目标：

BACKGROUND & AIMS: :Soybean [Glycine max (L.) Merr.] embryogenic cultures were transformed by particle bombardment with the feedback-insensitive tobacco anthranilate synthase (AS) gene ASA2 driven by the CaMV 35S promoter and selected using hph as the selectable marker gene. Only one of eight regenerated lines that set seed and contained ASA2 expressed the gene highly and contained increased free tryptophan (Trp) levels in leaves, seeds and embryogenic cultures. Leaf extracts of the ASA2 expressing line contained about twice as much AS enzyme activity as the untransformed control and this activity was only slightly more feedback-insensitive. Amino acid analysis showed that both leaves and embryogenic tissue cultures of the ASA2 expressing line had four to five-times the normal levels of free Trp and slightly higher free tyrosine and phenylalanine. The seed total Trp content was only slightly increased. Metabolic profiling-analysis by GC-MS detected no other consistent differences. These studies show that the ASA2 gene can be expressed in soybean and that modest changes in Trp synthesis occurs.

背景与目标： : 大豆 [Glycine max (L.) Merr。] 用反馈不敏感的烟草邻氨基苯甲酸合酶 (AS) 基因ASA2进行粒子轰击转化，该基因由CaMV 35s启动子驱动，并使用hph作为选择标记基因进行选择。结实种子并含有ASA2的八个再生品系中只有一个高度表达该基因，并在叶片，种子和胚发生培养物中含有增加的游离色氨酸 (Trp) 水平。ASA2表达系的叶片提取物的酶活性是未转化对照的酶活性的两倍，并且该活性仅对反馈不敏感。氨基酸分析表明，ASA2表达系的叶片和胚发生组织培养物的游离Trp水平是正常水平的4至5倍，游离酪氨酸和苯丙氨酸略高。种子总Trp含量仅略有增加。通过gc-ms进行的代谢分析没有发现其他一致的差异。这些研究表明，ASA2基因可以在大豆中表达，并且Trp合成发生适度变化。

BACKGROUND & AIMS: :Aboriginal Australians, including Aboriginal Health Workers (AHWs), smoke at rates double the non-Aboriginal population. This study utilized concept mapping methodology to identify and prioritize culturally relevant strategies to promote smoking cessation in AHWs. Stakeholder participants included AHWs, other health service employees and tobacco control personnel. Smoking cessation strategies (n = 74) were brainstormed using 34 interviews, 3 focus groups and a stakeholder workshop. Stakeholders sorted strategies into meaningful groups and rated them on perceived importance and feasibility. A concept map was developed using multi-dimensional scaling and hierarchical cluster analyses. Ten unique clusters of smoking cessation strategies were depicted that targeted individuals, family and peers, community, workplace and public policy. Smoking cessation resources and services were represented in addition to broader strategies addressing social and environmental stressors that perpetuate smoking and make quitting difficult. The perceived importance and feasibility of clusters were rated differently by participants working in health services that were government-coordinated compared with community-controlled. For health service workers within vulnerable populations, these findings clearly implicate a need for contextualized strategies that mitigate social and environmental stressors in addition to conventional strategies for tobacco control. The concept map is being applied in knowledge translation to guide development of smoking cessation programs for AHWs.

背景与目标： : 澳大利亚原住民，包括土著卫生工作者 (ahw)，吸烟率是非土著人口的两倍。这项研究利用概念映射方法来确定和确定与文化相关的策略以促进ahw戒烟。利益相关者参与者包括AHWs，其他卫生服务员工和烟草控制人员。通过34次访谈，3个焦点小组和利益相关者研讨会，对戒烟策略 (n = 74) 进行了头脑风暴。利益相关者将策略分为有意义的组，并根据感知的重要性和可行性对其进行评分。使用多维缩放和分层聚类分析开发了概念图。描述了十种独特的戒烟策略，这些策略针对个人，家庭和同龄人，社区，工作场所和公共政策。除更广泛的策略外，还提供了戒烟资源和服务，以解决使吸烟永久化并使戒烟困难的社会和环境压力源。与社区控制相比，在政府协调的卫生服务中工作的参与者对集群的重要性和可行性的评价有所不同。对于弱势人群中的卫生服务工作者，这些发现显然暗示了除了传统的烟草控制策略之外，还需要有针对性的策略来减轻社会和环境压力。概念图已应用于知识翻译中，以指导ahw戒烟计划的开发。

BACKGROUND & AIMS: :Previous research indicates that tobacco craving predicts relapse to smoking among adult smokers attempting to quit. We hypothesized a similar relationship between craving and lapse (any smoking following a period of abstinence) among adolescent smokers during the treatment phase of a clinical trial. A visit was considered a lapse visit if the participant reported smoking or had a carbon monoxide level of 7 ppm or greater subsequent to an abstinent visit. A total of 34 participants (mean age = 14.9 years [SD = 1.3]; mean cigarettes/day = 18.0 [SD = 7.6]; mean Fagerström Test for Nicotine Dependence score = 6.8 [SD = 1.34]; 65% female), were included in the present analysis of 167 treatment visits. Logistic regression analyses showed a positive relationship between degree of craving, measured by the Questionnaire on Smoking Urges, and lapse during smoking cessation treatment (p = .013). Additionally, linear regression analyses demonstrated a strong positive association between cigarettes smoked per day and craving scores (p<.001). Taken together with other data, these findings suggest that degree of craving might influence tobacco abstinence for adolescent smokers. Thus monitoring and addressing craving appears useful to increase the success of adolescent smoking cessation.

背景与目标： : 先前的研究表明，对烟草的渴望预示着试图戒烟的成年吸烟者的吸烟复发。我们假设在临床试验的治疗阶段，青少年吸烟者的渴望和戒烟 (禁欲一段时间后吸烟) 之间存在相似的关系。如果参与者报告吸烟或在禁欲访视后一氧化碳水平达到7 ppm或更高，则该访视被认为是短暂访视。共有34名参与者 (平均年龄 = 14.9岁 [SD = 1.3]; 平均香烟/天 = 18.0 [SD = 7.6]; 平均fagerstr ö m测试的尼古丁依赖性评分 = 6.8 [SD = 1.34]; 65% 名女性) 被包括在167治疗访问的当前分析中。Logistic回归分析显示，通过吸烟冲动问卷测量的渴望程度与戒烟治疗期间的失误之间存在正相关关系 (p = .013)。此外，线性回归分析表明，每天吸烟与渴望得分之间存在很强的正相关 (p<.001)。结合其他数据，这些发现表明，渴望程度可能会影响青少年吸烟者的戒烟。因此，监测和解决渴望似乎有助于提高青少年戒烟的成功率。

BACKGROUND & AIMS: :The objective of this work was to characterize trends over time in urinary excretion of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) among cigarette smokers in the US. We identified 35 studies presenting data that either reported, or could be converted to, common units of total urinary NNAL excretion as pmol/mg creatinine. The studies spanned 18years, reported urinary NNAL excretion estimates for 61 defined populations, and included a combined total of 3941 study participants. Analyses show that urinary NNAL excretion trends downward with study publication year, and the trend is statistically significant. The trend does not appear to be accounted for by a reduction in cigarettes smoked per day by study participants over the same time period. This trend is consistent with reductions in tobacco specific nitrosamine (TSNA) levels in both cigarette tobacco filler and mainstream cigarette smoke observed over the past decade and with efforts by the tobacco industry and the agricultural community to reduce levels of TSNAs in tobacco and cigarette smoke.

背景与目标： : 这项工作的目的是描述美国吸烟者中4-(甲基亚硝基氨基)-1-(3-吡啶基)-1-丁醇 (NNAL) 的尿排泄随时间的趋势。我们确定了35项研究，这些研究提供的数据要么报告了，要么可以转换为总尿NNAL排泄的常见单位，即pmol/mg肌酐。这项研究历时18年，报告了61个定义人群的尿NNAL排泄估计值，总共包括3941名研究参与者。分析表明，随着研究发表年份的增加，尿NNAL排泄量呈下降趋势，并且该趋势具有统计学意义。在同一时期，研究参与者每天吸烟的减少似乎并不能解释这种趋势。这一趋势与过去十年中观察到的卷烟烟草填料和主流卷烟烟气中烟草特定亚硝胺 (TSNA) 水平的降低以及烟草业和农业界为降低烟草和卷烟烟气中的TSNA水平而做出的努力是一致的。

BACKGROUND & AIMS: AIMS:Lack of adherence to smoking cessation medication regimens is assumed to play a significant role in limiting their effectiveness. This study aimed to assess evidence for this assumption. METHODS:A systematic search was conducted, supplemented by expert consultation, of papers reporting on randomized trials and observational studies examining the association between adherence to cessation medication and the success of quit attempts. To rule out reverse causality, only studies where adherence was assessed prior to relapse were included. Five studies met the inclusion criteria and results were extracted independently by two researchers. Heterogeneity between studies precluded a pooled analysis of the data. RESULTS:Studies varied widely with regard to both the definition of adherence and outcome measures. The included studies only addressed adherence to nicotine replacement therapy. One study of lozenge use found that the amount of medication used between 1 and 2 weeks after the quit date predicted abstinence at 6 weeks [adjusted odds ratio (OR) for 'high' versus 'low' lozenge use 1.25; 95% confidence interval (CI) = 1.05-1.50; P < 0.02]. Similarly, one study found a significant impact of oral nicotine consumption during the first week on abstinence at 4 weeks (adjusted OR per additional mg/day = 1.05; CI = 1.01-1.10). Another study found that participants using nicotine replacement therapy for at least 5 weeks were significantly more likely to self-report continuous abstinence at 6 months. The remaining two studies failed to find a significant effect of treatment duration on outcome at 1 and 2 years but had very low power to detect such an effect. CONCLUSIONS:There is modest evidence to support the assumption that lack of adherence to nicotine replacement therapy regimens undermines effectiveness in clinical studies.

背景与目标：

BACKGROUND & AIMS: BACKGROUND:The economic consequences of environmental tobacco smoke (ETS) have been simulated using models. We examined the individual-level association between ETS exposure and medical costs among Japanese nonsmoking women. METHODS:This population-based cohort study enrolled women aged 40 to 79 years living in a rural community. ETS exposure in homes at baseline was assessed with a self-administered questionnaire. We then collected health insurance claims data on direct medical expenditures from 1995 through 2007. Using generalized linear models with interaction between ETS exposure level and age stratum, average total monthly expenditure (inpatient plus outpatient care) per capita for nonsmoking women highly exposed and moderately exposed to ETS were compared with expenditures for unexposed women. We performed separate analyses for survivors and nonsurvivors. RESULTS:We analyzed data from 4870 women. After adjustment for potential confounding factors, survivors aged 70 to 79 who were highly exposed to ETS incurred higher expenditures than those who were not exposed. We found no significant difference in expenditures between moderately exposed and unexposed women. Total expenditures were not significantly associated with ETS exposure among survivors aged 40 to 69 or nonsurvivors of any age stratum. CONCLUSIONS:We calculated individual-level excess medical expenditures attributable to household exposure to ETS among surviving older women. The findings provide direct evidence of the economic burden of ETS, which is helpful for policymakers who seek to achieve the economically attractive goal of eliminating ETS.

背景与目标：

BACKGROUND & AIMS: BACKGROUND:Lung cancer has been the most common type of cancer in the world for several decades, and by 2008, there were approximately 1.61 million new cases, representing 12.7 % of all new cancers. It has been well known for many years that smoking causes lung cancer. Tobacco control measures have been regarded as the principal causes of the declines in smoking-related mortality, including mortality from lung cancer. METHODS:The Joinpoint Regression Program was used to analyze the long-term trends in lung cancer incidence rates from 1983 to 2008 in urban Shanghai. In addition, this study estimates how many fewer cases of lung cancer have occurred in urban Shanghai because of tobacco control activities. RESULTS:The lung cancer incidence rate among males decreased slightly by 0.6 % [95 % confidence interval (95 % CI) -0.1 to 1.3 %] from 1983 to 1999 and then declined rapidly at a rate of 3.8 % (95 % CI 2.1-5.4 %). Among females, the cancer incidence rate decreased by 0.1 % (95 % CI -0.2 to 0.5 %) from 1983 to 2008. Overall, we estimated that approximately 2,711 cases of lung cancer were averted among urban men in Shanghai between 2000 and 2008 because of the reduction in tobacco smoking. CONCLUSION:The reduction in tobacco smoking is a major factor in the decrease in the incidence rate of lung cancer. Sustained progress in tobacco control is essential.

背景与目标：

BACKGROUND & AIMS: :There is growing preclinical evidence for the involvement of glutamate in the behavioral actions of nicotine. The aim of this study, was to investigate the role of N-methyl-D-aspartate (NMDA) receptors in the cognitive and subjective effects of smoking in humans. Sixty regular smokers took part in this double-blind placebo controlled study, that investigated the effect of the NMDA-antagonist memantine (40 mg) and the nicotinic-receptor antagonist mecamylamine (10 mg) on smoking-induced improvement in performance of a task of sustained attention and on smoking-induced changes in subjective effects and craving. Increases in subjective ratings of 'buzzed' following smoking were reversed by memantine, but not by mecamylamine. In contrast, improvement on a Rapid Visual Information Processing task by smoking was opposed by mecamylamine, but not by memantine. Smoking reduced craving for cigarettes, but neither drug altered this effect. Our results suggest that glutamatergic mechanisms may have differential involvement in the subjective and cognitive actions of smoking. Further investigations using different ligands are warranted to fully characterize the role of glutamate underlying the consequences of smoking behavior.

背景与目标： : 越来越多的临床前证据表明谷氨酸参与尼古丁的行为行为。这项研究的目的是研究N-甲基-D-天冬氨酸 (NMDA) 受体在人类吸烟的认知和主观影响中的作用。60名普通吸烟者参加了这项双盲安慰剂对照研究，研究了NMDA拮抗剂美金刚 (40 mg) 和烟碱受体拮抗剂美加明胺 (10 mg) 对吸烟引起的持续关注任务性能的改善以及吸烟引起的主观影响和渴望变化的影响。美金刚逆转了吸烟后 “嗡嗡声” 的主观评分的增加，但美加明胺却没有。相反，美加明胺反对吸烟对快速视觉信息处理任务的改善，但美金刚反对。吸烟减少了对香烟的渴望，但两种药物都没有改变这种效果。我们的结果表明，谷氨酸能机制可能对吸烟的主观和认知作用有不同的参与。需要使用不同配体进行进一步研究，以充分表征谷氨酸在吸烟行为后果中的作用。