Female-specific cancers are the most common cancers in women worldwide. Early detection methods remain unavailable for most of these cancers, signifying that most of them are diagnosed at later stages. Furthermore, current treatment options for most female-specific cancers are surgery, radiation and chemotherapy. Although important milestones in molecularly targeted approaches have been achieved lately, current therapeutic strategies for female-specific cancers remain limited, ineffective and plagued by the emergence of chemoresistance, which aggravates prognosis. Recently, the application of nanotechnology to the medical field has allowed the development of novel nano-based approaches for the management and treatment of cancers, including female-specific cancers. These approaches promise to improve patient survival rates by reducing side effects, enabling selective delivery of drugs to tumor tissues and enhancing the uptake of therapeutic compounds, thus increasing anti-tumor activity. In this review, we focus on the application of nano-based technologies to the design of novel and innovative diagnostic and therapeutic strategies in the context of female-specific cancers, highlighting their potential uses and limitations.

译文

女性特异性癌症是全球女性最常见的癌症。对于大多数此类癌症,早期检测方法仍然不可用,这表明大多数癌症在后期被诊断出。此外,目前大多数女性特异性癌症的治疗选择是手术、放疗和化疗。尽管最近已经在分子靶向方法中取得了重要的里程碑,但目前针对女性特异性癌症的治疗策略仍然有限,无效且受到化学耐药性的困扰,这加剧了预后。最近,纳米技术在医学领域的应用允许开发新的基于纳米的方法来管理和治疗癌症,包括女性特异性癌症。这些方法有望通过减少副作用,使药物选择性地输送到肿瘤组织并增强治疗性化合物的摄取,从而提高抗肿瘤活性,从而提高患者的生存率。在这篇综述中,我们专注于基于纳米的技术在女性特异性癌症背景下设计新颖和创新的诊断和治疗策略中的应用,强调了它们的潜在用途和局限性。

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