Deficits or overexpression of neurotrophins cause neurodegenerative diseases and psychiatric disorders. These proteins are required for the maintenance of the function, plasticity and survival of neurons in the central (CNS) and peripheral nervous systems. Significant efforts have been devoted to developing therapeutic delivery systems that enable control of neurotrophin dosage in the brain. Here, we suggest that nanoparticulate carriers favoring targeted delivery in specific brain areas and minimizing biodistribution to the systemic circulation should be developed toward clinical benefits of neuroregeneration. We also provide examples of improved targeted neurotrophin delivery to localized areas in the CNS.

译文

神经营养蛋白的缺陷或过度表达会导致神经退行性疾病和精神疾病。这些蛋白质是维持中枢 (CNS) 和周围神经系统神经元的功能,可塑性和存活所必需的。已经做出了巨大的努力来开发能够控制大脑中神经营养蛋白剂量的治疗递送系统。在这里,我们建议应开发纳米颗粒载体,以促进特定脑区域的靶向递送并最大程度地减少向体循环的生物分布,以实现神经再生的临床益处。我们还提供了改善向中枢神经系统局部区域靶向神经营养蛋白递送的例子。

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