In vitro experiments demonstrated increased colony-forming capacity of erythroid, granulomonocytic, and mesenchymal progenitors of the bone marrow and parenchymal progenitor elements of the liver after treatment with immobilized hyaluronidase. Increased sensitivity of these progenitor cells to erythropoietin, granulocyte colony-stimulating factor, fibroblast growth factor, and stem cell factor, respectively, was demonstrated. Immobilized hyaluronidase enhanced the formation of tissue-specific hepatic CFU against the background of reduced yield of stromal precursors in liver tissue culture containing insulin.

译文

体外实验表明,用固定化透明质酸酶处理后,骨髓的红系,肉芽肿细胞和间充质祖细胞以及肝脏的实质祖细胞元素的集落形成能力增强。证实了这些祖细胞对促红细胞生成素,粒细胞集落刺激因子,成纤维细胞生长因子和干细胞因子的敏感性增加。在含有胰岛素的肝组织培养物中基质前体产量降低的背景下,固定化透明质酸酶增强了组织特异性肝CFU的形成。

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