Facile fabrication of nanostructured surface is of great importance for the use of titanium (Ti) implants in biomedical field. In this study, a low-cost and easy-to-operate method called HPT (hydrothermal & pressure) here has been developed and used to fabricate the expected nanostructured surface on Ti substrates. The effects of experimental parameters on the morphology of Ti surface were investigated and characterized. The results indicated that by altering the hydrothermal pressure, NaOH concentration and treating time, surface nanostructure like nanopetals or nanoflakes could be formed on the surface of Ti substrates. The orthogonal experiments were conducted to demonstrate the optimized operation conditions. A formation mechanism of the nanostructured titanate layer was proposed, revealing that the nanostructured layer could be formed via a special upward and downward co-growth manner. In vitro cell culture showed that the HPT treated Ti substrates, especially the T-10 sample, could greatly enhance the cell-material interactions, i.e. the cell proliferation and differentiation, focal protein adhesion, and osteogenic factor expression. The HPT method paves a new way to modify the surface of Ti implants with better bioactivity and promising prospect for future biomedical applications.

译文

纳米结构表面的简便制造对于在生物医学领域中使用钛 (Ti) 植入物非常重要。在这项研究中,已经开发了一种称为HPT (水热 & 压力) 的低成本且易于操作的方法,并将其用于在Ti衬底上制造预期的纳米结构表面。研究并表征了实验参数对Ti表面形貌的影响。结果表明,通过改变水热压力,NaOH浓度和处理时间,可以在Ti基材表面形成类似纳米颗粒或纳米薄片的表面纳米结构。进行正交实验以证明优化的操作条件。提出了纳米结构钛酸盐层的形成机理,揭示了纳米结构层可以通过特殊的向上和向下共生长方式形成。体外细胞培养表明,经HPT处理的Ti底物,尤其是T-10样品,可以大大增强细胞与物质的相互作用,即细胞增殖和分化,聚焦蛋白粘附和成骨因子的表达。HPT方法为修饰Ti植入物表面提供了一种新方法,具有更好的生物活性,并有望在未来的生物医学应用中获得广阔的前景。

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