The objective of this study was to synthesize and characterize a thermally responsive polymer-metal nanocomposite system comprised of a solid gold nanoparticle core and thermally responsive interpenetrating polymer network (IPN) shell, which was surface functionalized or PEGylated with a covalently bound linear poly(ethylene glycol) chain layer. Gold nanoparticles (50 nm diameter) were prepared using standard gold chloride and citrate reduction method. These particles were then encapsulated inside of a polyacrylamide (PAAm)/poly(acrylic acid) (PAA) IPN shell via an in situ inverse emulsion polymerization. The surface of the nanocomposite system was then PEGylated via covalent grafting of a linear methoxy-PEG-N-hydroxysuccinimide (M.W. 3400) to the primary amine groups of the PAAm network. Scanning and transmission electron microscopy were used to confirm the successful synthesis and encapsulation of gold nanoparticles within the IPN shell. Dynamic light scattering was used to examine the temperature swelling response of the IPN particles. Zeta-potential analysis was used to confirm the successful PEGylation of the final nanocomposite system.

译文

本研究的目的是合成和表征热响应聚合物-金属纳米复合材料体系,该体系由固体金纳米颗粒核和热响应互穿聚合物网络 (IPN) 壳组成,该体系被共价结合的线性聚乙二醇链层表面官能化或聚乙二醇化。使用标准氯化金和柠檬酸盐还原法制备了直径为50 nm的金纳米颗粒。然后通过原位反相乳液聚合将这些颗粒封装在聚丙烯酰胺 (PAAm)/聚 (丙烯酸) (PAA) IPN壳内。然后通过将线性甲氧基-PEG-N-羟基琥珀酰亚胺 (M.W. 3400) 共价接枝到PAAm网络的伯胺基团,使纳米复合体系的表面聚乙二醇化。扫描和透射电子显微镜用于确认金纳米颗粒在IPN壳中的成功合成和封装。动态光散射用于检查IPN颗粒的温度溶胀响应。Zeta电位分析用于确认最终纳米复合材料系统的成功peg化。

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