Polymer nanoparticles offer significant benefits for improving delivery of biological therapeutics such as DNA and proteins, as they allow the cargo to be protected until it is delivered to a target cell. However, there are still challenges with achieving efficient delivery to the optimal cellular region. One significant roadblock is escape of nanoparticles from within the endosomal/lysosomal compartments into the cytosol. Here, we review the recent advances in understanding endosomal escape of polymer nanoparticles. We also discuss the current progress on investigating how nanoparticle structure can control endosomal escape. It is important to understand the fundamental biological processes that govern endosomal escape in order to design more effective therapeutic delivery systems.

译文

聚合物纳米颗粒为改善生物疗法 (例如DNA和蛋白质) 的递送提供了显着的好处,因为它们允许保护货物直到将其递送到靶细胞为止。然而,实现向最佳蜂窝区域的有效递送仍然存在挑战。一个重要的障碍是纳米颗粒从内体/溶酶体区室逃逸到细胞质中。在这里,我们回顾了理解聚合物纳米颗粒的内体逃逸的最新进展。我们还讨论了研究纳米颗粒结构如何控制内体逃逸的最新进展。重要的是要了解控制内体逃逸的基本生物学过程,以便设计更有效的治疗递送系统。

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