In view of minimally-invasive clinical interventions, laser tissue soldering assisted by plasmonic nanoparticles is emerging as an appealing concept in surgical medicine, holding the promise of surgeries without sutures. Rigorous monitoring of the plasmonically-heated solder and the underlying tissue is crucial for optimizing the soldering bonding strength and minimizing the photothermal damage. To this end, we propose a non-invasive, non-contact, and non-ionizing modality for monitoring nanoparticle-assisted laser-tissue interaction and visualizing the localized photothermal damage, by taking advantage of the unique sensitivity of terahertz radiation to the hydration level of biological tissue. We demonstrate that terahertz radiation can be employed as a versatile tool to reveal the thermally-affected evolution in tissue, and to quantitatively characterize the photothermal damage induced by nanoparticle-assisted laser tissue soldering in three dimensions. Our approach can be easily extended and applied across a broad range of clinical applications involving laser-tissue interaction, such as laser ablation and photothermal therapies.

译文

鉴于微创的临床干预措施,由等离子体纳米粒子辅助的激光组织焊接正在成为外科医学中一个吸引人的概念,具有无缝线手术的希望。对等离子体加热的焊料和下面的组织进行严格的监控对于优化焊接强度和最大程度地减少光热损伤至关重要。为此,我们提出了一种非侵入性,非接触和非电离方式,用于监测纳米颗粒辅助的激光与组织的相互作用,并通过利用太赫兹辐射对生物组织水合水平的独特敏感性来可视化局部光热损伤。我们证明,太赫兹辐射可以用作一种通用工具,以揭示组织中热影响的演化,并定量表征由纳米颗粒辅助的激光组织焊接在三个维度上引起的光热损伤。我们的方法可以轻松地扩展并应用于涉及激光-组织相互作用的广泛临床应用,例如激光消融和光热疗法。

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