Scaffolds made of aligned nanofibers are favorable for nerve regeneration due to their superior nerve cell attachment and proliferation. However, it is challenging not only to produce a neat mat or a conduit form with aligned nanofibers but also to use these for surgical applications as a nerve guide conduit due to their insufficient mechanical strength. Furthermore, no studies have been reported on the fabrication of aligned nanofibers and randomly-oriented nanofibers on the same mat. In this study, we have successfully produced a mat with both aligned and randomly-oriented nanofibers by using a novel electrospinning set up. A new conduit with a highly-aligned electrospun mat is produced with this modified electrospinning method, and this proposed conduit with favorable features, such as selective permeability, hydrophilicity and nerve growth directional steering, were fabricated as nerve guide conduits (NGCs). The inner surface of the nerve conduit is covered with highly aligned electrospun nanofibers and is able to enhance the proliferation of neural cells. The central part of the tube is double-coated with randomly-oriented nanofibers over the aligned nanofibers, strengthening the weak mechanical strength of the aligned nanofibers.

译文

由排列的纳米纤维制成的支架由于其优越的神经细胞附着和增殖而有利于神经再生。然而,由于它们的机械强度不足,不仅要生产整齐的垫或具有对齐的纳米纤维的导管形式,而且要将它们用作外科手术应用作为神经导管是具有挑战性的。此外,还没有关于在同一垫子上制备取向的纳米纤维和随机取向的纳米纤维的研究报道。在这项研究中,我们通过使用新颖的静电纺丝装置成功地生产出了具有对齐和随机取向的纳米纤维的垫子。用这种改进的静电纺丝方法生产了一种具有高度对准的电纺垫的新导管,并将这种具有良好特性 (例如选择性渗透性,亲水性和神经生长定向转向) 的导管制成神经导管 (NGCs)。神经导管的内表面覆盖有高度排列的电纺纳米纤维,能够增强神经细胞的增殖。管的中心部分在对齐的纳米纤维上双重涂覆有随机取向的纳米纤维,增强了对齐的纳米纤维的弱机械强度。

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