The purpose of this work was to develop a type of tissue-engineering scaffold or drug-delivery carrier with the capability of encapsulation and controlled release of dual drugs. In this study, Rhodamine B and bovine serum albumin (BSA) were successfully incorporated into nanofibers by means of blending or coaxial electrospinning. The morphology of composite nanofibers was studied by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The composite nanofibrous mats made from coaxial electrospinning were characterized by X-ray diffraction. In vitro dual-drug release behaviors from composite nanofibrous mats were investigated. From the drug-release profiles, it shows that the location where the drug or protein is put into (into the core or shell of the nanofibers) can affect the drug-release profile in the coaxially electrospun fibers. The results imply that the drug- and/or protein-release profile in composite fibrous mats made from electrospinning can be controlled by altering the coaxial electrospinning process and has significant implications for a wide range of applications such as tissue regeneration, combined therapies or even cancer treatments.

译文

这项工作的目的是开发一种具有包封和控制双重药物释放能力的组织工程支架或药物递送载体。在这项研究中,罗丹明b和牛血清白蛋白 (BSA) 通过共混或同轴静电纺丝成功地掺入了纳米纤维中。通过扫描电子显微镜 (SEM) 和透射电子显微镜 (TEM) 研究了复合纳米纤维的形态。通过x射线衍射对由同轴静电纺丝制成的复合纳米纤维垫进行了表征。研究了复合纳米纤维垫的体外双重药物释放行为。从药物释放曲线可以看出,药物或蛋白质放入 (进入纳米纤维的芯或壳) 的位置会影响同轴电纺纤维中的药物释放曲线。结果表明,由静电纺丝制成的复合纤维垫中的药物和/或蛋白质释放曲线可以通过改变同轴静电纺丝工艺来控制,并且对广泛的应用 (例如组织再生,联合疗法或甚至癌症) 具有重大意义治疗。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录