Protein nanofibers are emerging as useful biological nanomaterials for a number of applications, but to realize these applications requires a cheap and readily available source of fibril-forming protein material. We have identified fish lens crystallins as a feedstock for the production of protein nanofibers and report optimized methods for their production. Altering the conditions of formation leads to individual protein nanofibers assembling into much larger structures. The ability to control the morphology and form higher order structures is a crucial step in bottom up assembly of bionanomaterials. Cell toxicity assays suggest no adverse impact of these structures on mammalian cell proliferation. There are many possible applications for protein nanofibers; here we illustrate their potential as templates for nanowire formation, with a simple gold plating process.

译文

蛋白质纳米纤维正在成为许多应用的有用生物纳米材料,但是要实现这些应用,需要廉价且易于获得的原纤维形成蛋白质材料来源。我们已经确定了鱼眼晶体蛋白作为生产蛋白质纳米纤维的原料,并报告了优化的生产方法。改变形成条件会导致单个蛋白质纳米纤维组装成更大的结构。控制形态和形成更高阶结构的能力是自下而上组装生物材料的关键一步。细胞毒性试验表明,这些结构对哺乳动物细胞增殖没有不利影响。蛋白质纳米纤维有许多可能的应用; 在这里,我们通过简单的镀金工艺来说明它们作为纳米线形成模板的潜力。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录