The aim of this study was to develop controlled drug delivery by network scaffolds based on self-assembling peptide RADAFI and RADAFII. These two peptides self-assembled into interconnected nanofibrilar network structures with distinct physical morphologies. The hydrogels were also utilized for entrapment and release of some model guests, promising their future application as a drug delivery vehicle. Fickian diffusion controlled the release kinetics. Furthermore, the obtained release function was dependent on both rational design of the peptides used for hydrogel formation and choice of the entrapped molecules. On the basis of the striking different releases of these two peptide scaffolds, we suggested that guest size and lipophilicity influenced the release competitively. The release of RADAFI system was dominated by guest size, and the guest lipophilicity controlled the release behavior in RADAFII system. In a word, this work would potentially provide a spatially and temporally controlled delivery system for some functional drugs in the future.

译文

这项研究的目的是开发基于自组装肽RADAFI和RADAFI的网络支架的受控药物递送。这两种肽自组装成具有不同物理形态的相互连接的纳米纤维网络结构。水凝胶还用于捕获和释放某些模型来宾,并有望将其作为药物输送载体。Fickian扩散控制了释放动力学。此外,获得的释放功能取决于用于水凝胶形成的肽的合理设计和截留分子的选择。基于这两种肽支架的显着不同释放,我们建议客体大小和亲脂性竞争性地影响释放。RADAFI系统的释放主要由来宾大小主导,来宾亲脂性控制了RADAFI系统的释放行为。总之,这项工作可能会在将来为某些功能药物提供空间和时间控制的递送系统。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录