1. The influence of perinatal and pubertal gonadal androgens on acetylcholinesterase (AChE) activity was studied in the hormone-sensitive levator ani (LA) and extensor digitorum longus (EDL) muscles of adult male rats (105 days). 2. The hormone was withdrawn by gonadectomy at various ages and the effects on AChE and weight were compared with those induced by chronic denervation of both muscles from adult rats. 3. Gonadectomy of infantile (2-30 days) rats prevented LA muscle growth, and reduced total AChE activity to values similar to those found in denervated muscles (15% of control). The EDL muscles were slightly affected and only in rats castrated on the 2nd postnatal day. 4. When the rats were castrated at puberty (45 days), LA muscle weight and total AChE activity were reduced to 20% and 18% of control values, respectively. 5. Gonadectomy of adult (60 and 75 days) rats led to atrophy of the LA muscle (to 29% of control) and reduced the total AChE activity (to 40% of control). 6. AChE activity per unit weight was reduced by 30% in rats castrated from 5 to 20 days of age, and increased by 30% in both LA and EDL muscles from rats castrated in adulthood. Gonadectomy before puberty prevented total AChE in the LA from increasing above the levels detected in chronically denervated muscles. 7. Gonadectomy after puberty reduced total AChE of the LA but never to the extent caused by muscle denervation. 8. It is concluded that testosterone regulates AChE in the LA by early priming of the motoneuron and by pubertal stimulation of enzyme synthesis, the synthesis being dependent on intact innervation.

译文

1。在成年雄性大鼠 (105天) 的激素敏感性提ani (LA) 和趾长伸肌 (EDL) 肌肉中研究了围产期和青春期性腺雄激素对乙酰胆碱酯酶 (AChE) 活性的影响。2.在不同年龄的性腺切除术中停用激素,并将其对疼痛和体重的影响与成年大鼠两种肌肉慢性去神经支配引起的影响进行比较。3.婴儿 (2-30天) 大鼠的性腺切除术可防止LA肌肉生长,并将总AChE活性降低至与失神经肌肉相似的值 (对照15%)。EDL肌肉受到轻微影响,仅在出生后第二天cast割的大鼠中。4.当大鼠在青春期 (45天) 去势时,LA肌肉重量和总AChE活性分别降低至对照值的20% 和18%。5.成年 (60和75天) 大鼠的性腺切除术导致LA肌肉萎缩 (至对照29%) 并降低总AChE活性 (至对照40%)。6.在5至20日龄的大鼠中,每单位重量的AChE活性因30% 而降低,而在成年后被阉割的大鼠的LA和EDL肌肉中,每单位重量的AChE活性因30% 而增加。青春期前的性腺切除术可防止LA的总疼痛增加到慢性失神经肌肉中检测到的水平以上。7.青春期后的性腺切除术减少了LA的总疼痛,但从未达到由肌肉神经支配引起的程度。8.结论是,睾丸激素通过运动神经元的早期启动和青春期刺激酶合成来调节LA中的AChE,该合成取决于完整的神经支配。

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